cas 62717-42-4, 2-phenyl-4-azabicyclo[5.4.0]undeca-7,9,11-triene-9,10-diol | Articles data ｜lookchem

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62717-42-4

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Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue.
Substituted 1-phenyl-3-benzazepines (e.g., SKF 38393 and fenoldopam) exhibit stereoselectivity in moderately high-affinity binding to and partial agonist activation of D1 dopamine receptors. The 3-allyl (APB) and the 3-allyl-6-chloro (6-Cl-APB) analogues
Neumeyer,Kula,Baldessarini,Baindur
p. 1466 - 1471
(2007/10/02)

Absolute stereochemistry and dopaminergic activity of enantiomers of 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Resolution of the unique dopamine receptor agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (1) was achieved by a stereospecific multistep conversion of the readily separated enantiomers of its O,O,N-trimethylated diffractometric analysi
Kaiser,Dandridge,Garvey,Hahn,Sarau,Setler,Bass,Clardy
p. 697 - 703
(2007/10/02)

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Chemical Properties

Melting Point: 283-285 °C
Solubility:H2O: >5mg/mL
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
PSA: 52.49000
LogP: 3.50620

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