Palladium-Catalyzed Double and Single Carbonylation of Aryl Halides and Allylic Compounds
After a brief introduction summarizing the author's previous work concerning the double carbonylation of aryl halides catalyzed by palladium complexes, newly found catalytic processes (1) for converting allylic formates and chlorides into β,γ-unsaturated acids and (2) the double carbonylation of allylic chlorides to β,γ-unsaturated α-keto amides are described.Mechanisms which reasonably account for the catalytic processes are proposed on the basis of studies concerning the properties of the organopalladium complexes.
Yamamoto, Akio
p. 433 - 446
(2007/10/02)
General Synthesis of Ketones from Carboxylic Esters and Carboxamides by Use of Mixed Organolithium-Magnesium Reagents: Syntheses of Artemisia Ketone
The novel reagents formed by combination of Grignard reagents (RMgX) with lithium diisopropylamide (LDA) convert non-enolizable carboxylic esters or carboxamides into ketones which are protected from further reaction by their in situ conversion into enolates.These enolates can be trapped with electrophiles such as Me3SiCl and allyl bromide.The scope of this Grignard mono-addition is illustrated by two direct synthesis of artemisia ketone (14).
Fehr, Charles,Galindo, Jose,Perret, Roland
p. 1745 - 1752
(2007/10/02)
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