A convergent strategy toward the synthesis of lateriflorone (5) is described. Our approach is based on biosynthetic considerations and draws on a sequence of prenylation, oxygenation and Claisen reactions for the construction of chromenequinone 6, and a tandem Claisen/Diels-Alder reaction cascade for the synthesis of caged tricycle 7. Union of fragments 6 and 7 led to the synthesis of seco-lateriflorone (49).
Tisdale, Eric J.,Vong, Binh G.,Li, Hongmei,Kim, Sun Hee,Chowdhury, Chinmay,Theodorakis, Emmanuel A.
p. 6873 - 6887
(2007/10/03)
A khellin-like 7,7'-glycerol-bridged bischromone with anti-anaphylactic activity
The synthesis of the title compound 3 is described. Its performance in Passive Cutaneous Anaphylaxis (PCA) testing was evaluated.
Lowe,Maske,Muller
p. 255 - 259
(2007/10/02)
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