Direct Esterification of Phosphates with Various Halides and its Application to Synthesis of cAMP Alkyl Triesters
Esterification of phosphates with various halides, including acid chlorides, phosphoryl trichloride and chloride, was achieved in 57-99percent isolated yield using silver(I) oxide.The reaction was successfully applied to the preparation of phosphate triesters sensitive to acids and bases. cAMP benzyl esters were also prepared by this method.
A CONVENIENT SYNTHESIS OF ADENOSINE 3',5'-CYCLIC PHOSPHATE (cAMP) BENZYL AND METHYL TRIESTERS
The benzyl amd methyl triesters of cAMP were synthesized from cAMP tri-n-butylammonium salt by alkylation with alkyl halides in the presence of Na2CO3 in dimethylacetamide (DMA).