Reaction of Epoxides with Chlorocarbonylated Compounds Catalyzed by Hexaalkylguanidinium Chloride
Silica-supported guanidinium chloride (PBGSiCl) exhibits efficient chemo- and regiospecific catalytic activity in the ring opening of epoxides with various electrophiles.This reaction allows the preparation of β-chloro esters and β-chloro chloroformates in high yield under neutral conditions which offer product stability and ease of product isolation.