- Potassium ion fluorescent probe as well as preparation method and application thereof (by machine translation)
-
The invention relates to a potassium ion fluorescent probe and a preparation method and application thereof (I). The potassium ion fluorescent probe provided by the invention NK1 has the advantages of short synthesis steps and simple structure, wherein, the synthesis steps of the potassium ion fluorescent probe are K ACLE as follows. + To the identification unit BODIPY, the derivative serves TPP as a fluorophore and as a mitochondria targeting group and is matched, so that the potassium ion fluorescent probe has high selectivity and sensitivity in the process of recognizing potassium ions. The NK1 human cervical cancer (HeLa) cell is small in toxic and side effects, high in biocompatibility and capable of targeting mitochondria. In addition, the method provided by the NK1 invention can qualitatively monitor the intracellular or outflow of potassium ions in the cell mitochondria. (by machine translation)
- -
-
Paragraph 0078-0080; 0085-0087
(2019/11/21)
-
- Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists
-
Optimization starting with our lead compound 1 (IC50 = 4.9 nM) led to the identification of pyrrolidinyl phenylurea derivatives. Further modification toward improvement of the bioavailability provided (R)-1-(1-((6-fluoronaphthalen-2-yl)methyl)pyrrolidin-3-yl)-3-(2-(2- hydroxyethoxy)phenyl)urea 32 (IC50 = 1.7 nM), a potent and orally active CCR3 antagonist.
- Nitta, Aiko,Iura, Yosuke,Inoue, Hideki,Imaoka, Takayuki,Takahashi, Toshiya,Sato, Ippei,Morihira, Koichiro,Kubota, Hirokazu,Morokata, Tatsuaki,Takeuchi, Makoto,Ohta, Mitsuaki,Tsukamoto, Shin-Ichi
-
p. 6876 - 6881,6
(2020/09/02)
-
- Chromoionophore and method of determining potassium ions
-
The invention relates to methods of determining potassium ions in a sample, wherein the ions are contacted with a compound having chromophoric moiety and an ionophoric moiety, where the ionophoric moiety interacts with the potassium ions present in the sample, resulting in the chromophoric moiety changing its radiation absorption properties in the ultraviolet and visible regions of the spectrum. For example, a change in an intensity of an absorption maximum is measured and the ion concentration is determined accordingly.
- -
-
Page/Page column 13-14
(2011/06/25)
-
- A Highly efficient and selective turn-on fluorescent sensor for Cu2+ ion
-
A new fluorescent chemosensor based on an open-chain azacrown bearing a quinoline subunit was conveniently synthesized, which showed a remarkable enhanced fluorescent intensity in the presence of Cu2+ ion and a high selectivity toward Cu2+ ion over a wide range of tested metal ions in acetonitrile.
- Wang, Xuehua,Cao, Jing,Chen, Chuanfeng
-
scheme or table
p. 1777 - 1779
(2011/07/09)
-
- A fluorescent sensor with high selectivity and sensitivity for potassium in water
-
This communication describes a new optical sensor suitable for practical measurement of extracellular (serum or whole blood) potassium. The sensor responds rapidly and reversibly to changes in potassium concentrations typical of whole blood samples. No interferences from clinical concentrations of calcium or pH are observed, and the sodium interference is very minor. Excitation and emission occur in the visible light region. This new potassium sensor is currently used in the Roche OPTI CCA, a commercially available whole blood analyzer. Copyright
- He, Huarui,Mortellaro, Mark A.,Leiner, Marc J. P.,Fraatz, Robert J.,Tusa, James K.
-
p. 1468 - 1469
(2007/10/03)
-
- Triaza-cryptand and method of determining an alkali ion
-
The invention relates to a triaza-cryptand of the general Formula I wherein a is selected from the group consisting of 0 and 1, b and c independently are selected from the group consisting of 0 and 1, with the proviso that not both of b and c are 0, d is selected from the group consisting of 1, 2 and 3, e and f independently are selected from the group consisting of 0 and 1, with the proviso that not both of e and f are 0, R1and R2are either hydrogen or form an alkyl(C1-C4) benzene ring or an alkoxy(C1C4) benzene ring together with C1and C2, wherein C2is the para position, R3and R2are either hydrogen or form an alkyl(C1-C4) benzene ring or an alkoxy(C1-C4) benzene ring together with C3and C4, wherein C3is the para position, R5and R6are either hydrogen or form a benzene ring or a naphtalene ring together with C5and C6, R7and R8are either hydrogen or form an alkyl(C1-C4) benzene ring or an alkoxy(C1-C4) benzene ring together with C7and C8, wherein C8is the para position, R9and R10are either hydrogen or form an alkyl(C1-C4) benzene ring or an alkoxy(C1-C4) benzene ring together with C9and C10, wherein C9is the para position, X is a luminophoric moiety in ortho, para or meta position with respect to the nitrogen and m is selected from the group consisting of 0, 1 and 2. The triaza-cryptand of the invention is useful as a luminescence indicator for alkali ions.
- -
-
-