A practical and inexpensive 'convertible' isonitrile for use in multicomponent reactions
N-tert-Butylamides are readily converted into the corresponding carboxylic acids by simple nitrosation. The process, which occurs under mild nonaqueous conditions, leaves carboxylic esters untouched and transforms multicomponent reaction products into useful building blocks for further synthetic elaboration.
Le, Hoang V.,Fan, Lijun,Ganem, Bruce
supporting information; experimental part
p. 2209 - 2211
(2011/05/09)
SYNTHETIC APPLICATION OF PHENYLTHIO- AND PHENYLSULFONYLMETHYL ETHERS TO ALDEHYDES, METHYLALS, CARBOXYLIC ACIDS, AND ENOL OR DIENOL ETHERS
Novel synthetic application of the title compounds to aldehydes, methylals, carboxylic acids, and enol or dienol ethers has been newly developed.