- BENZIIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES AS SODIUM CHANNEL MODULATORS
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The invention relates to benzimidazole and imidazopyridine derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new Nav1.8 modulators of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7. X and Y are as defined in the description. Nav1.8 modulators are potentially useful in the treatment of a wide range of disorders, particularly pain.
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Page/Page column 179
(2013/08/15)
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- The regioselectivity of internal hydrogen abstraction by triplet o-tert-amylbenzophenone
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The title ketone undergoes triplet-state δ-hydrogen abstraction to produce two diastereomeric sets of 1-phenyl-1-indanols: the 2,3,3-trimethyl isomers 2Z and 2E by abstraction of a methylene hydrogen and the 3-methyl 3-ethyl isomers 1Z and 1E by abstracti
- Wagner, Peter J.,Pabon, Raul,Park, Bong-Ser,Zand, Ali R.,Ward, Donald L.
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p. 589 - 596
(2007/10/02)
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