- SUBSTITUTED-N-HETEROARYL COMPOUNDS AND USES THEREOF
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The present disclosure relates generally to compounds useful for the treatment and/or enhancement of cognitive function and negative symptoms associated with central nervous system disorders where the circuitry involving fast spiking PV+ interneurons and the production of cortical gamma oscillations is disrupted. The subject disclosure enables the manufacture of medicaments as well as compositions containing same for use in methods of therapy and prophylaxis of cognitive dysfunction and negative symptoms.
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Page/Page column 96-97
(2020/01/24)
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- BORON-CONTAINING SMALL MOLECULES
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This invention provides novel compounds of the following formula and pharmaceutical compositions containing such compounds.
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Paragraph 0247
(2015/02/19)
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- 1 -HYDROXY-BENZOOXABOROLES AS ANTIPARASITIC AGENTS
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Provided are compounds useful for controlling endoparasites both in animals and agriculture. Further provided are methods for controlling endoparasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling endoparasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. The claimed compounds are described by the following Markush formula:A typical example for a compound according to above formula is: A typical example for a compound according to above formula is:
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Page/Page column 51
(2014/10/03)
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- Proton Transfer Reactions of 2-Alkyl-4-(4-nitrophenylazo)resorcinol Monoanions with Hydroxide Ion in Me2SO-H2O Mixtures
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The kinetic behaviour observed for the removal of the hydrogen-bonded O...H...N proton from 2-alkyl-4-(4-nitrophenylazo)resorcinol monoanions by hydroxide ion in Me2SO-H2O mixtures depends on the solvent ratio and on the 2-alkyl substituent (methyl, ethyl or isopropyl).For example, for 2-isopropyl-4-(4-nitrophenylazo)resorcinol monoanion in aqueous solution and in 30percent (v/v) Me2SO-H2O the rate goes through a minimum as the hydroxide-ion concentration is increased.In 60 and 80percent (v/v) Me2SO-H2O a practically linear dependence of rate on hydroxide-ion concentration is observed whereas in 90percent (v/v) Me2SO-H2O the rate increases to a limiting value.The dependence of rate on hydroxide-ion concentration is determined by the relative values of the rate coefficients for attack of hydroxide ion on the hydrogen-bonded and non-hydrogen-bonded forms of the monoanion and the rate coefficients for their interconversion.The effects of the solvent and the 2-alkyl substituent are discussed.
- Hibbert, Frank,Phillips, Sian C.
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p. 571 - 574
(2007/10/02)
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- Process for the preparation of resorcinol derivatives
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2-Substituted-4,6-di-t-butylresorcinol represented by the general formula: STR1 wherein R represents a straight or branched alkyl group having 1 to 20 carbon atoms, a straight or branched alkenyl group having 2 to 20 carbon atoms and at least one double bond, or an aralkyl group, but the tertiary carbon atom of R is free from direct bonding to the benzene nucleus, is prepared by allowing 4,6-di-t-butylresorcinol to react with a halogen compound represented by the general formula: wherein R has the same meaning as defined above, and X represents a halogen atom, excluding the X bonded to the tertiary carbon of R, in an aqueous alkali solution. By further debutylization of the 2-substituted-4,6-t-butylresorcinol, 2-substituted resorcinol represented by the general formula: STR2 wherein R has the same meaning as defined above, but the tertiary carbon of R is free from direct bonding to the benzene nucleus, is prepared.
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