- TPE based aggregation induced emission fluorescent sensors for viscosity of liquid and mechanical properties of hydrogel
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Two amphiphilic TPE E/Z isomers with aggregation induced emission (AIE) property have been synthesized and characterized. The logarithmic fluorescent intensity of the two molecules was in positive relationship with logarithmic viscosity of liquid. To note
- Wang, Na,Yao, Hang,Tao, Qi,Sun, Jing,Ma, Hao,Wang, Yang,Zhou, ChengCheng,Fan, Hongying,Shao, Hongxia,Qin, Aijian,Su, Dawei,Wang, Chenyin,Chong, Hui
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supporting information
p. 252 - 256
(2021/08/13)
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- FLUORINATED AMINE OXIDE SURFACTANTS
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Compositions including one or more fluorochemical surfactants of the formula: (I) where Rf is a perfluoroalkyl group, each of R1, R2 and R3 are C1-C20 alkyl, alkoxy, or aryl; and R4 is alkylene, arylene of a combination thereof. R4 is preferably an alkylene of 1-20 carbons that may be cyclic or acyclic, may optionally contain catenated or terminal heteroatoms selected from the group consisting of N, O, and S. Most preferably R4 is an alkylene of 2-10 carbon atoms. Described are anionic N-substituted fluorinated amine oxide surfactants, and use thereof in cleaning and in acid etch solutions. The cleaning and etch solutions are used with a wide variety of substrates, for example, in the cleaning and etching of silicon oxide-containing substrates.
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- Modulating optical and electrochemical properties of perylene dyes by twisting aromatic π-system structures
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Three highly fluorescent perylene bisimide dyes were synthesized, where aromatic π-system structures are twisted to different degree by steric hindrance of two or four substitution groups at bay position. Light-emitting colours of these dye solutions can be modulated from green, yellow to red, and their fluorescence quantum yields increase up to approximate 100% with increasing the π-system twisting, which can be considered for new class of wavelength-tunable dye lasers. π-Twisted dyes are more sensitive to microenvironment changes. Thus, they are better fluorescence probe and sensory materials than planar dyes. Electrochemical cyclic voltammetry measurements revealed that these dyes are suitable for n-type optoelectrical devices and materials. These dye solids display near infra-red emission at 600–850 nm. Owing to strong π-π stacking interaction, planar dye solid loses its outstanding optical properties compared to its solution. In contrast, π-twisted dye solids retain their excellent optical properties including narrow emission bands and relatively high fluorescence quantum yields due to the suppression of π-π stacking interaction. Exceptional fluorescence polarization phenomena were observed for these π-twisted dye solids. These optical results revealed that π-twisted perylene bisimide dyes are more excellent optical materials than planar dyes.
- Wang, Ying,Zhang, Qi,Gong, Junbo,Zhang, Xin
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-
- Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors
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CD4 mimics are small molecules that inhibit the interaction of gp120 with CD4. We have developed several CD4 mimics. Herein, hybrid molecules consisting of CD4 mimics with a long alkyl chain or a PEG unit attached through a self-cleavable linker were synthesized. In anti-HIV activity, modification with a PEG unit appeared to be more suitable than modification with a long alkyl chain. Thus, hybrid molecules of CD4 mimics, with PEG units attached through an uncleavable linker, were developed and showed high anti-HIV activity and low cytotoxicity. In investigation of pharmacokinetics in a rhesus macaque, a hybrid compound had a more effective PK profile than that of the parent compound, and intramuscular injection was a more useful administration route to maintain the high blood concentration of the CD4 mimic than intravenous injection. The presented hybrid molecules of CD4 mimics with a PEG unit would be practically useful when combined with a neutralizing antibody.
- Kobayakawa, Takuya,Tsuji, Kohei,Konno, Kiju,Himeno, Ai,Masuda, Ami,Yang, Tingting,Takahashi, Kohei,Ishida, Yusuke,Ohashi, Nami,Kuwata, Takeo,Matsumoto, Kaho,Yoshimura, Kazuhisa,Sakawaki, Hiromi,Miura, Tomoyuki,Harada, Shigeyoshi,Matsushita, Shuzo,Tamamura, Hirokazu
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supporting information
p. 1481 - 1496
(2021/02/27)
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- NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION
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Nerve-specific fluorophore formulations of Formula (I) for direct or systemic administration are described. The formulations can be used in fluorescence-guided surgery (FGS) to aid in nerve preservation during surgical interventions.
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Page/Page column 37-38
(2021/08/13)
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- Construction of Janus dendrimers through a self-assembly approach involving chiral discrimination at a focal point
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A strategy to build Janus dendrimersviathe chirality-directed self-assembly of heteroleptic Zn(ii) BOX complexes is reported. The method allows quantitative synthesis of Janus dendrimersin situwithout the need for purifications. Each dendritic domain of t
- Zhou, John,Cole, Ashley M.,Menuey, Elizabeth M.,Kilway, Kathleen V.,Moteki, Shin A.
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supporting information
p. 6404 - 6407
(2021/07/02)
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- Polaron Delocalization in Donor–Acceptor Polymers and its Impact on Organic Electrochemical Transistor Performance
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Donor–acceptor (D-A) polymers are promising materials for organic electrochemical transistors (OECTs), as they minimize detrimental faradaic side-reactions during OECT operation, yet their steady-state OECT performance still lags far behind their all-donor counterparts. We report three D-A polymers based on the diketopyrrolopyrrole unit that afford OECT performances similar to those of all-donor polymers, hence representing a significant improvement to the previously developed D-A copolymers. In addition to improved OECT performance, DFT simulations of the polymers and their respective hole polarons also reveal a positive correlation between hole polaron delocalization and steady-state OECT performance, providing new insights into the design of OECT materials. Importantly, we demonstrate how polaron delocalization can be tuned directly at the molecular level by selection of the building blocks comprising the polymers’ conjugated backbone, thus paving the way for the development of even higher performing OECT polymers.
- Moser, Maximilian,Savva, Achilleas,Thorley, Karl,Paulsen, Bryan D.,Hidalgo, Tania Cecilia,Ohayon, David,Chen, Hu,Giovannitti, Alexander,Marks, Adam,Gasparini, Nicola,Wadsworth, Andrew,Rivnay, Jonathan,Inal, Sahika,McCulloch, Iain
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supporting information
p. 7777 - 7785
(2021/03/03)
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- One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
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Efficient viral or nonviral delivery of nucleic acids is the key step of genetic nanomedicine. Both viral and synthetic vectors have been successfully employed for genetic delivery with recent examples being DNA, adenoviral, and mRNA-based Covid-19 vaccines. Viral vectors can be target specific and very efficient but can also mediate severe immune response, cell toxicity, and mutations. Four-component lipid nanoparticles (LNPs) containing ionizable lipids, phospholipids, cholesterol for mechanical properties, and PEG-conjugated lipid for stability represent the current leading nonviral vectors for mRNA. However, the segregation of the neutral ionizable lipid as droplets in the core of the LNP, the "PEG dilemma", and the stability at only very low temperatures limit their efficiency. Here, we report the development of a one-component multifunctional ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA that exhibits high activity at a low concentration of ionizable amines organized in a sequence-defined arrangement. Six libraries containing 54 sequence-defined IAJDs were synthesized by an accelerated modular-orthogonal methodology and coassembled with mRNA into dendrimersome nanoparticles (DNPs) by a simple injection method rather than by the complex microfluidic technology often used for LNPs. Forty four (81%) showed activity in vitro and 31 (57%) in vivo. Some, exhibiting organ specificity, are stable at 5 °C and demonstrated higher transfection efficiency than positive control experiments in vitro and in vivo. Aside from practical applications, this proof of concept will help elucidate the mechanisms of packaging and release of mRNA from DNPs as a function of ionizable amine concentration, their sequence, and constitutional isomerism of IAJDs.
- Atochina-Vasserman, Elena N.,Billingsley, Margaret M.,Huang, Ning,Kim, Kyunghee,Liu, Matthew,Maurya, Devendra S.,Mitchell, Michael J.,Ni, Houping,Ona, Nathan,Percec, Virgil,Pochan, Darrin J.,Shahnawaz, Hamna,Weissman, Drew,Xiao, Qi,Zhang, Dapeng
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supporting information
p. 12315 - 12327
(2021/08/20)
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- An unnatural tripeptide structure containing intramolecular double H-bonds mimics a turn hairpin conformation
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A series of unnatural tripeptides, each consisting of two aromatic γ-amino acid residues and an ?-amino acid residue, are designed to probe their folding into hairpin conformations. The ?-amino acid residues, with aliphatic or aromatic spacers of different sizes, serve as the loop of the hairpins. Studies based on one-dimensional (1D) 1H NMR performed at different concentrations, solvent polarity, and temperature, along with 2D-NMR studies, demonstrated that the doubly H-bonded aromatic γ-amino acid residues play important roles in driving these tripeptides into the hairpin conformation. The loop based on 5-aminovaleric acid, which offers a four-carbon (CH2)4 spacer, enhanced the stability of the corresponding hairpin, while loops having a shorter, a longer and a more rigid spacer disfavored the formation of the hairpins. Results from computational studies are in good agreement with the experimental observations. Furthermore, the crystal structure of peptide 1b revealed the expected hairpin conformation in the solid state. This turn motif, which contains H-bonded aromatic γ-amino acid residues as the core unit and an ?-amino acid residue serving as the loop, provides a new platform that can be used to obtain a variety of turn conformations by incorporating diverse amino acids into the loops.
- Gong, Bing,Li, Xiao-Qi,Liu, Jin-Yu,Liu, Rui,Lu, Zhong-Lin,Song, Jun-Jie,Sun, Xue-Yi,Tang, Quan
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p. 4359 - 4363
(2021/05/31)
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- Designing Nonfullerene Acceptors with Oligo(Ethylene Glycol) Side Chains: Unraveling the Origin of Increased Open-Circuit Voltage and Balanced Charge Carrier Mobilities
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Despite the recent rapid development of organic solar cells (OSCs), the low dielectric constant (?r=3–4) of organic semiconducting materials limits their performance lower than inorganic and perovskite solar cells. In this work, we introduce oligo(ethylene glycol) (OEG) side chains into the dicyanodistyrylbenzene-based non-fullerene acceptors (NIDCS) to increase its ?r up to 5.4. In particular, a NIDCS acceptor bearing two triethylene glycol chains (NIDCS-EO3) shows VOC as high as 1.12 V in an OSC device with a polymer donor PTB7, which is attributed to reduced exciton binding energy of the blend film. Also, the larger size grain formation with well-ordered stacking structure of the NIDCS-EO3 blend film leads to the increased charge mobility and thus to the improved charge mobility balance, resulting in higher JSC, FF, and PCE in the OSC device compared to those of a device using the hexyl chain-based NIDCS acceptor (NIDCS-HO). Finally, we fabricate NIDCS-EO3 devices with various commercial donors including P3HT, DTS-F, and PCE11 to show higher photovoltaic performance than the NIDCS-HO devices, suggesting versatility of NIDCS-EO3.
- Cui, Junjie,Park, Jung-Hwa,Kim, Dong Won,Choi, Min-Woo,Chung, Hae Yeon,Kwon, Oh Kyu,Kwon, Ji Eon,Park, Soo Young
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supporting information
p. 2481 - 2488
(2021/07/26)
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- Biotin-decorated NIR-absorbing nanosheets for targeted photodynamic cancer therapy
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Targeted photodynamic therapy (PDT) is one of the promising approaches for the selective killing of cancerous cells without affecting the normal cells, and hence designing new strategies for targeted PDT is extremely important. Herein we report the design and synthesis of a new class of nanosheets derived from the self-assembly of the iodo-BODIPY-biotin conjugate as a photosensitizer for targeted PDT applications. The nanosheet exhibits a high extinction coefficient in the NIR region, high singlet oxygen efficiency, no toxicity in the dark and cell targeting ligands (biotin) on the surface, which are necessary features required for an ideal photosensitizer. Overexpression of sodium-dependent multivitamin transporters (SMVTs) in HeLa and A549 (biotin receptor positive cell lines) is explored for the selective uptake of the nanophotosensitizer through receptor mediated endocytosis (interaction between biotin and SMVT). Control experiments using a biotin receptor negative cell line (WI-38) are also carried out to confirm that the specific interaction between the SMVTs and biotin is mainly responsible for the selective uptake of the photosensitizer. Efficient killing of cancerous cells is demonstrated upon light irradiation through the generation of singlet oxygen and other reactive oxygen species around the cellular environment.
- Perumal, Devanathan,Golla, Murali,Pillai, Kavya S.,Raj, Gowtham,Krishna P. K., Anusree,Varghese, Reji
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supporting information
p. 2804 - 2810
(2021/04/07)
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- COLOR MATERIAL DISPERSION LIQUID, COMPOSITION, FILM, OPTICAL FILTER AND DISPLAY DEVICE
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A color material dispersion liquid including a color material, which is a salt-forming compound of an organic dye with a heteropolyoxometalate, a dispersant and a solvent, wherein the organic dye is at least one organic dye selected from the group consist
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-
Paragraph 0346-0347
(2021/06/26)
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- Lithium-Conducting Self-Assembled Organic Nanotubes
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Supramolecular polymers are compelling platforms for the design of stimuli-responsive materials with emergent functions. Here, we report the assembly of an amphiphilic nanotube for Li-ion conduction that exhibits high ionic conductivity, mechanical integrity, electrochemical stability, and solution processability. Imine condensation of a pyridine-containing diamine with a triethylene glycol functionalized isophthalaldehyde yields pore-functionalized macrocycles. Atomic force microscopy, scanning electron microscopy, and in solvo X-ray diffraction reveal that macrocycle protonation during their mild synthesis drives assembly into high-aspect ratio (>103) nanotubes with three interior triethylene glycol groups. Electrochemical impedance spectroscopy demonstrates that lithiated nanotubes are efficient Li+ conductors, with an activation energy of 0.42 eV and a peak room temperature conductivity of 3.91 ± 0.38 × 10-5 S cm-1. 7Li NMR and Raman spectroscopy show that lithiation occurs exclusively within the nanotube interior and implicates the glycol groups in facilitating efficient Li+ transduction. Linear sweep voltammetry and galvanostatic lithium plating-stripping tests reveal that this nanotube-based electrolyte is stable over a wide potential range and supports long-term cyclability. These findings demonstrate how the coupling of synthetic design and supramolecular structural control can yield high-performance ionic transporters that are amenable to device-relevant fabrication, as well as the technological potential of chemically designed self-assembled nanotubes.
- Strauss, Michael J.,Hwang, Insu,Evans, Austin M.,Natraj, Anusree,Aguilar-Enriquez, Xavier,Castano, Ioannina,Roesner, Emily K.,Choi, Jang Wook,Dichtel, William R.
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supporting information
p. 17655 - 17665
(2021/11/04)
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- Modular amphiphilic poly(aryl ether)-based supramolecular nanomicelles: An efficient endocytic drug carrier
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A rationally designed amphiphilic poly(aryl ether)-based dendrimer self-assembles into nanomicelles and exhibits tunable morphology upon varying the hydrophilic chain length. The 30 nm-sized dendrimer nanomicelles successfully entrapped Doxorubicin, demonstrated the sustained release of Doxorubicin and can successfully penetrate cancer cells through caveolae-dependent endocytosis, compared to the free drug.
- Kannan, Ramya,Datta, Ayan,Prabakaran, Palani,Prasad, Edamana,Muthuvijayan, Vignesh
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supporting information
p. 12695 - 12698
(2021/12/04)
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- A Molecular Strategy to Lock-in the Conformation of a Perylene Bisimide-Derived Supramolecular Polymer
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Locking-in the conformation of supramolecular assemblies provides a new avenue to regulate the (opto)electronic properties of robust nanoscale objects. In the present contribution, we show that the covalent tethering of a perylene bisimide (PBI)-derived s
- Ashcraft, Adam,Bernard, Brianna,Husainy, Dalia,Liu, Chuan,Liu, Kaixuan,Mukhopadhyay, Arindam,Olivier, Jean-Hubert,Paulino, Victor,Phan, Tina
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supporting information
p. 7487 - 7493
(2020/03/13)
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- Fine-tuning thio-pyridazinediones as SMDC scaffolds (with intracellular thiol release via a novel self-immolative linker)
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Herein we report the synthesis of a library of thioalkyl- and thioaryl-pyridazinediones for thiol-based self-immolative release of cargo. A bisthioaryl-pyridazinedione is shown to be stable to serum protein albumin but unstable in intracellular conditions
- Fernández, Marcos,Shamsabadi, André,Chudasama, Vijay
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supporting information
p. 1125 - 1128
(2020/02/03)
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- Selective sensing of sulfate anions in water with cyclopeptide-decorated gold nanoparticles
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The interaction of cyclopeptides bound to the surface of mixed monolayer-protected gold nanoparticles with sulfate anions causes the crosslinking and concomitant precipitation of the nanoparticles from aqueous solutions even in presence of an excess of competing anions, thus allowing the naked eye detection of sulfate in water.
- Bartl, Julia,Koch, Marcus,Kubik, Stefan,Reinke, Lena
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supporting information
p. 10457 - 10460
(2020/10/02)
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- Optical detection of di- And triphosphate anions with mixed monolayer-protected gold nanoparticles containing zinc(II)-dipicolylamine complexes
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Gold nanoparticles covered with a mixture of ligands of which one type contains solubilizing triethylene glycol residues and the other peripheral zinc(II)-dipicolylamine (DPA) complexes allowed the optical detection of hydrogenphosphate, diphosphate, and triphosphate anions in water/methanol 1:2 (v/v). These anions caused the bright red solutions of the nanoparticles to change their color because of nanoparticle aggregation followed by precipitation, whereas halides or oxoanions such as sulfate, nitrate, or carbonate produced no effect. The sensitivity of phosphate sensing depended on the nature of the anion, with diphosphate and triphosphate inducing visual changes at significantly lower concentrations than hydrogenphosphate. In addition, the sensing sensitivity was also affected by the ratio of the ligands on the nanoparticle surface, decreasing as the number of immobilized zinc(II)-dipicolylamine groups increased. A nanoparticle containing a 9:1 ratio of the solubilizing and the anion-binding ligand showed a color change at diphosphate and triphosphate concentrations as low as 10 μmol/L, for example, and precipitated at slightly higher concentrations. Hydrogenphosphate induced a nanoparticle precipitation only at a concentration of ca. 400 μmol/L, at which the precipitates formed in the presence of diphosphates and triphosphates redissolved. A nanoparticle containing fewer binding sites was more sensitive, while increasing the relative number of zinc(II)-dipicolylamine complexes beyond 25% had a negative impact on the limit of detection and the optical response. Transmission electron microscopy provided evidence that the changes of the nanoparticle properties observed in the presence of the phosphates were due to a nanoparticle crosslinking, consistent with the preferred binding mode of zinc(II)-dipicolylamine complexes with phosphate anions which involves binding of the anion between two metal centers. This work thus provided information on how the behavior of mixed monolayer-protected gold nanoparticles is affected by multivalent interactions, at the same time introducing a method to assess whether certain biologically relevant anions are present in an aqueous solution within a specific concentration range.
- Reinke, Lena,Bartl, Julia,Koch, Marcus,Kubik, Stefan
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supporting information
p. 2687 - 2700
(2020/12/01)
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- Targeting G Protein-Coupled Receptors with Magnetic Carbon Nanotubes: The Case of the A3 Adenosine Receptor
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The A3 adenosine receptor (AR) is a G protein-coupled receptor (GPCR) overexpressed in the membrane of specific cancer cells. Thus, the development of nanosystems targeting this receptor could be a strategy to both treat and diagnose cancer. Iron-filled carbon nanotubes (CNTs) are an optimal platform for theranostic purposes, and the use of a magnetic field can be exploited for cancer magnetic cell sorting and thermal therapy. In this work, we have conjugated an A3AR ligand on the surface of iron-filled CNTs with the aim of targeting cells overexpressing A3ARs. In particular, two conjugates bearing PEG linkers of different length were designed. A docking analysis of A3AR showed that neither CNT nor linker interferes with ligand binding to the receptor; this was confirmed by in vitro preliminary radioligand competition assays on A3AR. Encouraged by this result, magnetic cell sorting was applied to a mixture of cells overexpressing or not the A3AR in which our compound displayed indiscriminate binding to all cells. Despite this, it is the first time that a GPCR ligand has been anchored to a magnetic nanosystem, thus it opens the door to new applications for cancer treatment.
- Pineux, Florent,Federico, Stephanie,Klotz, Karl-Norbert,Kachler, Sonja,Michiels, Carine,Sturlese, Mattia,Prato, Maurizio,Spalluto, Giampiero,Moro, Stefano,Bonifazi, Davide
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supporting information
p. 1909 - 1920
(2020/09/11)
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- Pyridine-containing BODIPY and quaternary ammonium salt photosensitizer thereof, and preparation method and applications of quaternary ammonium salt photosensitizer
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The invention belongs to the field of drug synthesis, and relates to a pyridine-containing BODIPY compound represented by a general formula (I), and a quaternary ammonium salt thereof, particularly toa pyridine quaternary ammonium salt photosensitizer, a
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-
Paragraph 0022; 0023; 0024
(2020/06/17)
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- DETECTION METHOD
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The present invention relates to an optical sensing element for detection of a narcotic, the optical sensing element comprising a fluorescent sensing compound provided on a substrate, wherein emission of the fluorescent sensing compound is quenched in the
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Page/Page column 25; 33; 34
(2019/06/05)
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- Dendrimeric Nanoparticles for Two-Photon Photodynamic Therapy and Imaging: Synthesis, Photophysical Properties, Innocuousness in Daylight and Cytotoxicity under Two-Photon Irradiation in the NIR
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The synthesis and the photophysical properties of a new class of fully organic monodisperse nanoparticles for combined two-photon imaging and photodynamic therapy are described. The design of such nanoparticles is based on the covalent immobilization of a dedicated quadrupolar dye that combines excellent two-photon absorbing (2PA) properties, fluorescence and singlet oxygen generation ability, in a phosphorous-based dendrimeric architecture. First, a bifunctional quadrupolar dye bearing two different grafting moieties, a phenol function and an aldehyde function, was synthesized. It was then covalently grafted through its phenol function to a phosphorus-based dendrimer scaffold of generation 1. The remaining aldehyde functions were then used to continue the dendrimer synthesis up to generation 2, introducing finally 24 water-solubilizing triethyleneglycol chains at its periphery. A dendrimer confining 12 photoactive quadrupolar units in its inner scaffold and showing water solubility was thus obtained. Interestingly, the G1 and G2 dendrimers retain some fluorescence as well as significant singlet oxygen production efficiencies while they were found to show very high 2PA cross-sections in a broad range of the NIR biological spectral window. Hydrophilic dendrimer G2 was tested in vitro on breast cancer cells, first in one- and two-photon microscopy, which allowed for visualization of their cell internalization, then in two-photon photodynamic therapy. While being nontoxic in the dark and, more importantly, under exposure to daylight, dendrimer G2 proved to be a very efficient cell-death inducer only under two-photon irradiation in the NIR.
- Sourdon, Aude,Gary-Bobo, Magali,Maynadier, Marie,Garcia, Marcel,Majoral, Jean-Pierre,Caminade, Anne-Marie,Mongin, Olivier,Blanchard-Desce, Mireille
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p. 3637 - 3649
(2019/02/14)
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- Effect of furan π-spacer and triethylene oxide methyl ether substituents on performance of phenothiazine sensitizers in dye-sensitized solar cells
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Conjugated π-spacers are used to improve the light harvesting properties of sensitizers for dye-sensitized solar cells. In several recent works, furan has outperformed other popular π-spacers such as thiophene and phenyl. One of the best performing phenothiazine dyes in the literature has no π-spacer, and two polar triethylene oxide methyl ether (TEOME) chains. Herein we report the synthesis and evaluation of three novel sensitizers based on EO3, investigating the effect of introducing a furan linker and stepwise removal of the TEOME chains. The furan linker redshifted the onsets in the IPCE spectra by 50 nm and improved the PCE by up to 29% compared to EO3, despite lowering the VOC by more than 60 mV. The best sensitizer of the study was AFB-30, with an average PCE of 5.86% (JSC = 10.41 mA cm-2, VOC = 783 mV, FF = 0.73) under 1 sun AM 1.5G illumination.
- Buene, Audun Formo,Boholm, Nanna,Hagfeldt, Anders,Hoff, B?rd Helge
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supporting information
p. 9403 - 9410
(2019/06/24)
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- Palladium-induced transformation of nematic liquid crystals to robust metallogel comprising self-assembled nanowires
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The formation of a nematic liquid-crystalline phase in the bulk along with gelation of a novel asymmetric bolaamphiphilic NDI scaffold has been demonstrated. Further, a discrete metal NDI complex that is capable of forming a robust metallogel through wrapping of the NDI core with the oxyethylene chains of the neighboring molecules has been synthesized.
- Maiti, Bappa,Bhattacharjee, Subham,Bhattacharya, Santanu
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p. 12651 - 12654
(2019/10/28)
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- Polyether chain substituted alkyne-based (I) complex and preparation method and application thereof
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The invention discloses a polyether chain substituted alkyne-based (I) complex and a preparation method and application thereof, and belongs to the technical field of gold (I) complexes. The polyetherchain substituted alkyne-based (I) complex comprises a
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-
Paragraph 0048; 0049; 0057; 0058
(2019/07/16)
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- MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE
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The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
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-
Paragraph 00181; 00197
(2019/03/05)
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- Pure white light emission and charge transfer in organogels of symmetrical and unsymmetrical π-chromophoric oligo-: P -(phenyleneethynylene) bola-amphiphiles
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Two novel bola-amphiphilic oligo-p-(phenyleneethynylene) (OPE) dicarboxylates have been synthesized having non-polar and mixed-polar side chains. This led to gelation in both with vesicular morphology. Upon in situ loading of a suitable dye and redox-active molecule, pure white light emitting and charge transfer (CT)-gels, respectively, were realized.
- Roy, Syamantak,Samanta, Debabrata,Kumar, Pramod,Maji, Tapas Kumar
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supporting information
p. 275 - 278
(2018/01/12)
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- Hydrophilic metal-organic polyhedra, preparation method thereof and gas separation membrane comprising the same
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The present invention relates to a hydrophilic metal-organic polyhedron, a production method thereof, and a gas separator including the same. More specifically, by producing the hydrophilic metal-organic polyhedron containing a polyethylene oxide-based organic ligand and mixing the same with a crosslinked polyethylene oxide polymer, the hydrophilic metal-organic polyhedron can be applied as a gas separator which exhibits a high CO_2/N_2 permeation selectivity.COPYRIGHT KIPO 2018
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Paragraph 0116-0117
(2018/05/29)
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- Thermodynamics of Halide Binding to a Neutral Bambusuril in Water and Organic Solvents
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Driving forces of anion binding in water in contrast to nonpolar environments are of high interest because of their relevance to biology and medicine. Here we report a neutral bambusuril macrocycle (1), soluble in both water and nonpolar solvents due to decoration with 12 polyethylene glycol-based substituents. The new bambusuril has the highest affinity for I- in pure water ever reported for a synthetic macrocycle relying on hydrogen bonding interactions rather than metal coordination or Coulombic forces. Isothermal titration calorimetry (ITC) experiments in nine different solvents, ranging from polar water to nonpolar carbon tetrachloride, provided insight into the forces responsible for halide binding by bambusurils. The different importance of anion solvation and solvent expulsion from the cavity of the macrocycle in various solvents is illustrated by the fact that halide binding in water and chloroform is exclusively driven by favorable enthalpy with an entropic penalty, while in alcohols and nonpolar solvents, both favorable enthalpy and entropy contribute to anion encapsulation. DFT calculations and correlation of thermodynamic data with the solvent Swain acity parameter further underscore the importance of solvent effects on anion binding by bambusurils.
- Fiala, Tomas,Sleziakova, Kristina,Marsalek, Kamil,Salvadori, Karolina,Sindelar, Vladimir
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p. 1903 - 1912
(2018/02/23)
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- A silibinin ether derivatives and its synthetic method and application
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The invention discloses a derivative of silybin ethers, and a synthetic method and application thereof. The derivative of the silybin ethers has a structural formula as shown in a formula I, wherein R1 is a -(CH2CH2O)mR4 group; R2 is hydrogen or the -(CH2
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Paragraph 0060-0063
(2018/05/24)
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- Self-Assembled Carcerand-like Cage with a Thermoregulated Selective Binding Preference for Purification of High-Purity C60 and C70
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Fullerene molecules have attracted considerable interest because of the unique curved aromatic π-conjugated systems. However, the complicated and costly technologies for purification of highly pure fullerenes hamper easy access to these attractive molecul
- Sun, Weidong,Wang, Ying,Ma, Lishuang,Zheng, Lu,Fang, Weihai,Chen, Xuebo,Jiang, Hua
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p. 14667 - 14675
(2018/11/27)
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- High Affinity Neutral Bodipy Fluorophores for Mitochondrial Tracking
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We report the first high affinity neutral Bodipy fluorophores for selective imaging of mitochondria with notable sensitivity (~100 nM) and insignificant cytotoxicity even at very high concentration (~100 μM), when tested against HeLa cells. Further, these fluorophores are chemically robust and require no special conditions for storage.
- Gayathri, Thumuganti,Karnewar, Santosh,Kotamraju, Srigiridhar,Singh, Surya Prakash
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supporting information
p. 618 - 622
(2018/06/29)
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- CONDUCTING POLYMERS AND USES THEREOF
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The present invention generally relates to the field of conducting polymers. More specifically, the present invention relates to polymerisable monomers comprising a probe capable of binding one or more nucleic acids or comprising a nucleic acid or an analogue thereof, conducting polymers comprising monomer units of such monomers, and methods of making such polymers. The present invention also relates to sensors comprising the polymers, sensor systems comprising the sensors, methods of making the sensors, and methods for determining the presence or absence or amount of targets employing the sensors. The present invention also relates to methods, systems and apparatuses for amplifying nucleic acids employing the conducting polymers.
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Page/Page column 68; 70; 71
(2018/03/28)
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- Phenanthroline derivative and preparation method and application thereof
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The invention provides a phenanthroline derivative and a preparation method and application thereof. The preparation method is simple, quick, convenient, easy in raw material acquisition, low in costand high in yield. A prepared product is high in solubil
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Paragraph 0033; 0034
(2018/08/28)
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- Small-molecule AIEE (aggregation-induced emission enhancement) light emitting material with triple-stimulation responsiveness and method for preparing small-molecule AIEE light emitting material
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The invention discloses a small-molecule AIEE (aggregation-induced emission enhancement) light emitting material with triple-stimulation responsiveness and a method for preparing the small-molecule AIEE light emitting material. The small-molecule AIEE lig
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Paragraph 0044; 0045; 0046
(2018/10/19)
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- Multistimuli-responsive small-molecule compound with aggregation-induced emission enhancement characteristics: preparation, properties and applications
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A novel multifunction luminescent small-molecule compound with hydrophilic chains was successfully designed and synthesized, which exhibited aggregation-induced emission enhancement (AIEE) characteristics. Even more interesting, it exhibited responsive be
- Li, Qiangjun,Yuan, Yongjie,He, Lifang,Liu, Shenglan,Zhang, Hailiang
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p. 20239 - 20248
(2018/12/13)
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- MECHANICALLY SHAPED 2-DIMENSIONAL COVALENT ORGANIC FRAMEWORKS
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Covalent organic frameworks (COFs) usually crystallize as insoluble powders and their processing for suitable devices has been thought to be limited. Here, it is demonstrated that COFs can be mechanically pressed into shaped objects having anisotropic ordering with preferred orientation between the hk0 and 00/ crystallographic planes. Pellets prepared from bulk COF powders impregnated with LiC1O4 displayed room temperature conductivity up to 0.26 mS cm-1 and stability up to 10.0 V (vs. Li+/Li0). This outcome portends use of COFs as solid-state electrolytes in batteries.
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Page/Page column 29; 30
(2018/02/28)
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- BODIPY-based high-sensitivity fluorescent probe and synthesis method and application thereof
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The invention relates to a BODIPY-based high-sensitivity fluorescent probe and a synthesis method and application thereof. A structural general formula of the probe is shown as (I), wherein Trigger is stimulant triggering groups, R1 and R2 are groups for regulating and controlling fluorescent transmission wavelength of the probe and introducing organelle targeting, and R1 and R2 are defined in the description. By the probe, detection of different substrates can be realized without changing mother nucleus structure of the probe by only changing different Trigger groups. In addition, according to different needs on wavelength and targeting, the mother nucleus structure of the probe can be quickly modified. By changing R1 and R2, maximum fluorescent emission wavelength of the probe can be changed, and the probe can target mitochondrion to realize detection of active substances in the mitochondrion. The probe has good biocompatibility, thereby being applicable to detecting biological systems. Application value of the fluorescent probe in the aspect of detecting bioactive molecules and protease over-expressed in inflammatory or tumor tissue has potential social benefit and economic benefit.
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Paragraph 0047; 0049; 0051
(2018/03/24)
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- Neutral iodotriazole foldamers as tetradentate halogen bonding anion receptors
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Neutral tetradentate halogen bond donor foldamers were synthesised and exhibit enhanced anion affinities over their hydrogen bonding analogues, displaying iodide selectivity over lighter halide, carboxylate and dihydrogen phosphate anions. A foldamer with a chiral (S)-binaphthol motif was demonstrated to distinguish between enantiomers of chiral anions.
- Borissov, Arseni,Lim, Jason Y. C.,Brown, Asha,Christensen, Kirsten E.,Thompson, Amber L.,Smith, Martin D.,Beer, Paul D.
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supporting information
p. 2483 - 2486
(2017/03/01)
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- Facile removal of tosyl chloride from tosylates using cellulosic materials, e.g., filter paper
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Excess tosyl chloride used in the tosylation of alcohols is quickly and easily removed by reacting it with cellulosic materials, e.g., filter paper, and filtering.
- Schoonover, Daniel V.,Gibson, Harry W.
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supporting information
p. 242 - 244
(2016/12/27)
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- Multimodal Probes: Superresolution and Transmission Electron Microscopy Imaging of Mitochondria, and Oxygen Mapping of Cells, Using Small-Molecule Ir(III) Luminescent Complexes
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We describe an Ir(III)-based small-molecule, multimodal probe for use in both light and electron microscopy. The direct correlation of data between light- and electron-microscopy-based imaging to investigate cellular processes at the ultrastructure level
- Shewring, Jonathan R.,Cankut, Ahmet J.,McKenzie, Luke K.,Crowston, Bethany J.,Botchway, Stanley W.,Weinstein, Julia A.,Edwards, Elizabeth,Ward, Michael D.
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supporting information
p. 15259 - 15270
(2017/12/27)
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- N-PHENYLMALEIMIDE DERIVATIVE AND MANUFACTURING METHOD THEREFOR, PRECURSOR OF N-PHENYLMALEIMIDE DERIVATIVE, POLYMER, PROTEIN ADHESION PREVENTION AGENT AND MEDICAL DEVICE
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PROBLEM TO BE SOLVED: To provide a polymer and a protein adhesion prevention agent that protein is less likely to adhere to a surface of a substrate or the like and a coating layer excellent in water resistance and heat resistance can be formed, and a med
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Paragraph 0096-0097
(2018/02/22)
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- Porphyrin compound which is high in water solubility and is capable of absorbing near infrared ray, and preparation method and applications thereof
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The invention belongs to the field of organic synthesis and drugs, and more specifically relates to a porphyrin compound which is high in water solubility and is capable of absorbing near infrared ray, and a preparation method and applications thereof. Ac
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Paragraph 0063; 0064; 0065; 0066; 0067
(2017/04/26)
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- Optical sensing of aqueous boron based on polymeric hydroxytriphenylene derivatives
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The detection of boron in natural water and wastewaters is still limited to a few methods, requiring a compromise between sensitivity, reliability and accessibility. Here we present a novel polymeric fluorescent boron sensor with excellent water solubility, boron sensitivity, ease of handling, which can be easily recovered and reused. The new off-on fluorescent boron sensor is able to detect and quantify ppb amounts of boron in water, with a limit of detection of 10 ppb of boron, both for boric acid and phenylboronic acid. The sensor was prepared by copolymerizing methacrylic acid with a polymerizable asymmetric hexa-substituted triphenylene, obtained by oxidative cyclization of biphenyl and catechol precursors.
- Areias,Da Costa,Alves,Baleiz?o,Farinha
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p. 4627 - 4634
(2017/02/05)
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- ALKYNYL INDAZOLE DERIVATIVE AND USE THEREOF
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The main object of the present invention is to provide a novel compound which has a VEGF receptor tyrosine kinase inhibitory activity and is useful as an active ingredient for the treatment of diseases accompanying angiogenesis or edema, for example, age-related macular degeneration or the like. The present invention includes, for example, an alkynyl indazole derivative represented by the following general formula (I), a pharmaceutical acceptable salt thereof, and a medicine containing thereof.
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Paragraph 0224; 0225
(2017/02/24)
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- Inclusion complexes of a new family of non-ionic amphiphilic dendrocalix[4]arene and poorly water-soluble drugs naproxen and ibuprofen
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The inclusion complexes of a new family of nonionic amphiphilic calix[4]arenes with the anti-inflammatory hydrophobic drugs naproxen (NAP) and ibuprofen (IBP) were investigated. The effects of the alkyl chain's length and the inner core of calix[4]arenes on the interaction of the two drugs with the calix[4]arenes were explored. The inclusion complexes of Amphiphiles 1a-c with NAP and IBP increased the solubility of these drugs in aqueous media. The interaction of 1a-c with the drugs in aqueous media was investigated through fluorescence, molecular modeling, and 1H-NMR analysis. TEM studies further supported the formation of inclusion complexes. The length of lipophilic alkyl chains and the intrinsic cyclic nature of cailx[4]arene derivatives 1a-c were found to have a significant impact on the solubility of NAP and IBP in pure water.
- Khan, Khalid,Lal Badshah, Syed,Ahmad, Nasir,Rashid, Haroon Ur,Mabkhot, Yahia
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- Supramolecular pathway selection of perylenediimides mediated by chemical fuels
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We demonstrate supramolecular pathway selection of a perylenediimide derivative in aqueous solution using chemically fueled redox reactions to control assembly/disassembly cycles. The number and frequency of cycles affect the nucleation and growth process
- Leira-Iglesias, Jorge,Sorrenti, Alessandro,Sato, Akihiro,Dunne, Peter A.,Hermans, Thomas M.
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supporting information
p. 9009 - 9012
(2016/07/21)
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- Photophysical properties of asymmetric and water-soluble dinuclear lanthanide complexes of poly glycol chain functionalized-benzoic acid derivative: Experimental and theoretical approaches
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New water-soluble lanthanide complexes with a poly glycol chain (-OEtOEtOEtOMe) functionalized benzoic acid derivative ligand were synthesized and photophysically characterized. The results indicate a formation of an asymmetric dinuclear lanthanide comple
- Bosshard,Brito,Monteiro,De Bettencourt-Dias,Mazali,Sigoli
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p. 101133 - 101141
(2016/11/09)
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- Interface-induced face-on orientation of the active layer by self-assembled diblock conjugated polyelectrolytes for efficient organic photovoltaic cells
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Systematic investigation of the instinctive self-assembly of diblock conjugated polyelectrolytes (CPEs) as electron transport layers (ETLs) on the arrangement and morphology of the upper active layer in polymer solar cells (PSCs) is usually ignored. The t
- Zhou, Dan,Cheng, Xiaofang,Xu, Haitao,Yang, Hanjun,Liu, Huimin,Wu, Feiyan,Chen, Lie,Chen, Yiwang
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supporting information
p. 18478 - 18489
(2016/12/09)
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- Kinetically Controlled Sequential Growth of Surface-Grafted Chiral Supramolecular Copolymers
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We report a facile strategy to grow supramolecular copolymers on Au surfaces by successively exposing a surface-anchored monomer to solutions of oppositely charged peptide comonomers. Charge regulation on the active chain end of the polymer sufficiently slows down the kinetics of the self-assembly process to produce kinetically trapped copolymers at near-neutral pH. We thereby achieve architectural control at three levels: The β-sheet sequences direct the polymerization away from the surface, the height of the supramolecular copolymer brushes is well-controlled by the stepwise nature of the alternating copolymer growth, and 2D spatial resolution is realized by using micropatterned initiating monomers. The programmable nature of the resulting architectures renders this concept attractive for the development of customized biomaterials or chiral interfaces for optoelectronics and sensor applications.
- Frisch, Hendrik,Fritz, Eva-Corinna,Stricker, Friedrich,Schmüser, Lars,Spitzer, Daniel,Weidner, Tobias,Ravoo, Bart Jan,Besenius, Pol
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supporting information
p. 7242 - 7246
(2016/07/06)
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