629655-23-8

Basic information

• Product Name: 2-CHLORO-3-NITROPYRIDIN-4-OL
• Synonyms: 2-CHLORO-3-NITROPYRIDIN-4-OL;2-Chloro-3-nitropyridin-4-ol, min. 95 %
• CAS NO: 629655-23-8
• Molecular Formula: C₅H₃ClN₂O₃
• Molecular Weight: 174.54
• Mol File: 629655-23-8.mol

Chemical Properties

• Boiling Point: 408.2 °C at 760 mmHg
• Flash Point: 200.7 °C
• Appearance: /
• Density: 1.664 g/cm³
• Refractive Index: 1.637
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.59±0.20(Predicted)
• CAS DataBase Reference: 2-CHLORO-3-NITROPYRIDIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-NITROPYRIDIN-4-OL(629655-23-8)
• EPA Substance Registry System: 2-CHLORO-3-NITROPYRIDIN-4-OL(629655-23-8)

Safety Data

• Hazardous Substances Data: 629655-23-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-3-NITROPYRIDIN-4-OL is utilized as an intermediate in the synthesis of pharmaceuticals, playing a crucial role in the development of new drugs. Its functional groups facilitate the creation of diverse chemical entities with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-CHLORO-3-NITROPYRIDIN-4-OL serves as an intermediate for the synthesis of various agrochemicals, contributing to the development of products that enhance crop protection and yield.
Used in Dye and Pigment Manufacturing:
2-CHLORO-3-NITROPYRIDIN-4-OL is employed in the manufacture of dyes and pigments, capitalizing on its chemical properties to produce a range of colorants for different applications, including textiles, plastics, and printing inks.
Used in Organic Syntheses:
As a versatile building block, 2-CHLORO-3-NITROPYRIDIN-4-OL is used in organic syntheses to create a variety of chemical compounds for research and industrial applications, taking advantage of its reactivity and functional group chemistry.

InChI:InChI=1/C5H3ClN2O3/c6-5-4(8(10)11)3(9)1-2-7-5/h1-2H,(H,7,9)

Upstream product

• 5975-12-2 2,4-dichloro-3-nitro-pyridine 
• 626-03-9 3-deazauracil 
• 89282-12-2 2,4-dihydroxy-3-nitropyridine 

Downstream Products

• 656237-77-3 N-[(1R)-1-(4-bromophenyl)ethyl]-4-chloro-3-nitropyridin-2-amine 
• 1590410-09-5 C₁₅H₁₃BrN₂O₃ 
• 1590410-10-8 C₁₄H₁₁BrN₂O₃ 
• 1590410-12-0 C₁₆H₁₅BrN₂O₄ 
• 1590410-15-3 C₂₆H₂₁F₃N₄O₅ 
• 1590410-13-1 C₂₀H₂₀N₄O₄ 
• 1590410-14-2 C₁₉H₁₈N₄O₄ 
• 1590406-96-4 C₁₈H₁₃F₃N₄O₄ 
• 1201681-60-8 8-hydroxy-1,4-dihydro-pyrido[2,3-b]pyrazine-2,3-dione 

Relevant articles and documents

PDE4 INHIBITOR

Provided are a PDE4 inhibitor and a use thereof in the preparation of a medicament for treating PDE4 related diseases. Specifically disclosed are the compound as shown in formula (I) and a pharmaceutically acceptable salt thereof.

1-SUBSTITUTED 1,2,3,4-TETRAHYDRO-1,7-NAPHTHYRIDIN-8-AMINE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR ANTAGONISTS

The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof has an EP4 receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of EP4 receptor associated diseases (e.g., rheumatoid arthritis, aortic aneurysm (e.g. abdominal aortic aneurysm, thoracic aortic aneurysm, thoracoabdominal aortic aneurysm etc.), endometriosis, ankylosing spondylitis, inflammatory breast cancer etc.) and the like.

ANTI-FIBROTIC PYRIDINONES

This application relates to polycyclic compounds with a pyridinone or pyridinone derivative core including, substituted pyridinones, 5,6- and 6,6- bicyclic heterocycles and substituted pyridine-thiones. This application also discloses methods of preparing these polycyclic compounds, pharmaceutical compositions and medicaments comprising said compounds and methods to treat, prevent or diagnose diseases, disorders or conditions associated with fibrosis.

ANTI-FIBROTIC PYRIDINONES

Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

PROCESS FOR PREPARATION OF NITROPYRIDINE DERIVATIVES

Disclosed here is a process for the preparation of nitropyridine derivatives of Formula (I) and its salt and precursors such as halogenated amino pyridines; Wherein; R1 is selected from amino group, hydroxyl group, acyl group, alkyl amino group, halogen atom, -NH - C (O) - R3; Where R3 is branched or linear alkyl group having 1 - 6 carbon atoms, or cycloalkyl group having 3 - 6 carbon atoms; R2 is selected from hydroxyl group, halogen atom, alkoxy group,

Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization

Thrombin-inhibitor X-ray crystal structures, in combination with the installation of binding elements optimized within the pyrazinone series of thrombin inhibitors, were utilized to transform a weak triazolopyrimidine lead into a series of potent oxazolop

Thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof.