Probing the pharmacophore for allosteric ligands of muscarinic M 2 receptors: SAR and QSAR studies in a series of bisquaternary salts of caracurine V and related ring systems
Allosteric effects on muscarinic acetylcholine M2 receptors were examined in a series of bisquaternary salts of the Strychnos alkaloid caracurine V (6) and related iso-caracurine V, tetrahydrocaracurine V, and bisnortoxiferine ring systems. The
Zlotos, Darius P.,Buller, Stefan,Stiefl, Nikolaus,Baumann, Knut,Mohr, Klaus
p. 3561 - 3571
(2007/10/03)
Stereochemistry of caracurine V
The 3D structure of the Strychnos alkaloid caracurine V was determined by means of NMR spectroscopy and semiempirical calculations. The previously unknown absolute configuration in the central eight-membered ring was assigned as (16R, 16'R, 17R, and 17'R)