630060-02-5

Basic information

• Product Name: 1-Thiaspiro[4.4]non-3-en-6-one,(+)-(9CI)
• CAS NO: 630060-02-5
• Molecular Formula: C₈H₁₀OS
• Molecular Weight: 154.23
• Product Categories: CYCLOPENTANE
• Mol File: 630060-02-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Thiaspiro[4.4]non-3-en-6-one,(+)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Thiaspiro[4.4]non-3-en-6-one,(+)-(9CI)(630060-02-5)
• EPA Substance Registry System: 1-Thiaspiro[4.4]non-3-en-6-one,(+)-(9CI)(630060-02-5)

Safety Data

• Hazardous Substances Data: 630060-02-5(Hazardous Substances Data)

Downstream Products

• 630060-22-9 diphenyl-carbamic acid 2-acetylamino-9-[6-(tert-butyl-dimethyl-silanyloxy)-1-thia-spiro[4.4]non-2-yl]-9H-purin-6-yl ester 
• 630059-58-4 Benzoic acid (5S,6R)-6-(tert-butyl-dimethyl-silanyloxy)-1-thia-spiro[4.4]non-3-yl ester 
• 630059-21-1 (3R,5S,6S)-3-Phenyl-1,4-dioxa-7-thia-dispiro[4.0.4.3]tridecan-2-one 
• 630059-33-5 (5S,6S)-1-Thia-spiro[4.4]nonan-6-ol 
• 630059-93-7 (3R,5S,6S)-3-Phenyl-1,4-dioxa-7-thia-dispiro[4.0.4.3]tridec-9-en-2-one 
• 630059-90-4 (3R,5S,6R)-3-Phenyl-1,4-dioxa-7-thia-dispiro[4.0.4.3]tridec-9-en-2-one 
• 630059-96-0 (3R,5R,6S)-3-Phenyl-1,4-dioxa-7-thia-dispiro[4.0.4.3]tridec-9-en-2-one 
• 630059-99-3 (3R,5R,6R)-3-Phenyl-1,4-dioxa-7-thia-dispiro[4.0.4.3]tridec-9-en-2-one 

Relevant articles and documents

C4'-spiroalkylated nucleosides having sulfur incorporated at the apex position.

Methodology based on the concept of thionium ion-initiated pinacolic ring expansion has been developed for accessing C4'-spirocyclic thionucleosides. The readily available racemic ketones 6 and 37 are conveniently resolved via their acetals with (R)-mandelic acid. Subsequent reactions beginning with utilization of the Pummerer rearrangement lend themselves to functionalization of the spirocyclic core and ultimately incorporation of the nucleosidic bases. Limitations to this strategy are pointed out. Acquisition of the alpha- and beta-isomers at C4' is equally facile. Absolute configurational assignments have been made possible by X-ray crystallography.