Practical convergent laboratory-scale synthesis of a CCR5 receptor antagonist
An efficient laboratory-scale synthesis has been developed for the selective CCR5 antagonist 1. The convergent route has a longest linear sequence of nine steps (15 steps overall), and has overall yields of 18-25%. The route has enabled the preparation of 550 g of 1.
Crawford, Jason B.,Chen, Gang,Carpenter, Bryon,Wilson, Trevor,Ji, Jenny,Skerlj, Renato T.,Bridger, Gary J.
experimental part
p. 109 - 116
(2012/05/31)
More Articles about upstream products of 630082-81-4