- Palladium-Catalyzed Ortho-Alkoxylation of N-Benzoyl α-Amino Acid Derivatives at Room Temperature
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An efficient palladium-catalyzed ortho-alkoxylation of N-benzoyl α-amino acid derivatives at room temperature has been explored. This novel transformation, using amino acids as directing groups, Pd(OAc)2 as catalyst, alcohols as the alkoxylation reagents, and PhI(OAc)2 as the oxidant, showed wide generality, good functional tolerance, and high monoselectivity and regioselectivity.
- Li, Shuangjie,Zhu, Wei,Gao, Feng,Li, Chunpu,Wang, Jiang,Liu, Hong
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p. 126 - 134
(2017/04/26)
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- A facile and rapid preparation of hydroxamic acids by hydroxylaminolysis using DBU as base
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While there are many protocols for the preparation of hydroxamic acids from their corresponding carboxylic acid or carboxylic ester precursors, most use strong mineral bases that can lead to carboxylic acid impurities that can be difficult to remove using standard chromatographic techniques. This problem is exacerbated when the carbonyl group is hindered. Herein, we communicate a robust hydroxylaminolysis protocol for the preparation of hydroxamic acids in high yield and purity.
- Beillard, Audrey,Bhurruth-Alcor, Yushma,Bouix-Peter, Claire,Bouquet, Karinne,Chambon, Sandrine,Clary, Laurence,Harris, Craig S.,Millois, Corinne,Mouis, Grégoire,Ouvry, Gilles,Pierre, Romain,Reitz, Arnaud,Tomas, Loic
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p. 2165 - 2170
(2016/05/02)
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- A new entry to antihypertensive active pharmaceutical ingredient, Irbesartan and its analogues
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A new synthesis of Irbesartan, an antihypertensive active pharmaceutical ingredient and its analogues is reported.
- Satyanarayana, Bollikonda,Sumalatha, Yasareni,Sridhar, Chaganti,Venkatraman, Sundaram,Reddy, Padi Pratap
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p. 323 - 328
(2007/10/03)
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