Pd(0)-based synthetic approaches to 1,1-disubstituted-3,4-dimethylenecyclopentanes as intermediates in the preparation of a,a-disubstituted amino acid derivatives possessing indane and diazaindane skeletons
A comparison is established between ethyl nitroacetate and ethyl N(diphenylmelhylene)glycinate as anionic glycine equivalents for the preparation of bicyclic or tricyclic a.adisubstituted amino acids. Palladiummediated approaches to 1.1disubstituted-3,4-di methylene cyclopentanes are presented (intramolecular reductive coupling of 2.6-dibromol.6dienes and cycloisomerization of 1.6enynes). Springer-Verlag Iberica 1997.
Loepez, Anna,Moreno-Manas, Marcial,Pleixats, Roser,Roglans, Anna
p. 355 - 362
(2007/10/03)
REACTIONS OF HALOGEN FLUORIDES XII. REACTION OF BROMINE TRIFLUORIDE WITH BROMINE-CONTAINING ESTERS. A NEW METHOD FOR THE SYNTHESIS OF FLUOROALKYL 2-FLUOROACRYLATES
Being weak Lewis bases, esters reduce the reactivity of bromine trifluoride in the substitutive fluorination of organic bromine derivatives.For this reason the rate of the reaction of bromine trifluoride with bromine-containing esters depends not only on the electronic characteristics of the substituents at the reaction center but also on the basicity of the ester.As a rule, the selectivity of the reaction increases with increase in the basicity of the ester.The reaction of bromine trifluoride or chlorine monofluoride with fluoroalkyl 2,3-dibromopropionates can be used successfully for the synthesis of monomers (fluoroalkyl 2-fluoroacrylates).
Kartashov, A. V.,Chuvatkin, N. N.,Boguslavskaya, L. S.
p. 2243 - 2248
(2007/10/02)
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