Catalytic Enantioselective Methylene C(sp3)?H Amidation of 8-Alkylquinolines Using a Cp*RhIII/Chiral Carboxylic Acid System
Catalytic enantioselective directed methylene C(sp3)?H amidation reactions of 8-alkylquinolines using a Cp*RhIII/chiral carboxylic acid (CCA) hybrid catalytic system are described. A binaphthyl-based chiral carboxylic acid efficiently differentiates between the enantiotopic methylene C?H bonds, which leads to the formation of C?N bonds with good enantioselectivity.