- Total synthesis of bioactive frustulosin and frustulosinol
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Stereum hirsutum is a pathogenic fungus involved in 'Esca', a trunk wood disease of grapevine. Among the metabolites isolated from the culture medium of this fungus, frustulosin (2a) shows a high phytotoxicity. A new simple and efficient method for the sy
- Goddard, Mary-Lorène,Tabacchi, Raffaele
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p. 909 - 911
(2007/10/03)
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- Total Synthesis of Frustulosin and Aurocitrin
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The regioselective total syntheses of the novel fungal antibiotics frustulosin (1) and aurocitrin (2) were accomplished from 3,6-dihydroxy-2-iodobenzaldehyde (10) which was prepared by a regiodirected metalation of 2,5-dimethylbenzyl vinyl ether to establish the 1,2,3,4-tetrasubstitution pattern of these compounds.The unsaturated side chains of these hydroquinone antibiotics were attached by using the iodo aldehyde functionalities.The structures of these antibiotics are confirmed by synthesis.
- Ronald, Robert C.,Lansinger, Janet M.,Lillie, Thomas S.,Wheeler, Carl J.
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p. 2541 - 2549
(2007/10/02)
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