cas 631912-19-1, 3-BROMO-4-FLUOROBENZENESULFONYL CHLORIDE | Articles data ｜lookchem

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631912-19-1

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Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions
Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.
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(2008/06/13)

NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS
Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.
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Page 435

(2010/02/05)

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Chemical Properties

Boiling Point: 319.8±27.0 °C(Predicted)
Density: 1.867±0.06 g/cm3 (20 ºC 760 Torr)
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
PSA: 42.52000
LogP: 3.59650

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