632334-60-2

Basic information

• Product Name: 2-Boc-4-(2-pyridyl)hoMopiperazine, 95%
• Synonyms: 2-Boc-4-(2-pyridyl)hoMopiperazine, 95%
• CAS NO: 632334-60-2
• Molecular Formula: C15H23N3O2
• Molecular Weight: 277.36202
• Mol File: 632334-60-2.mol

Chemical Properties

• Boiling Point: 405.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.105±0.06 g/cm3(Predicted)
• PKA: 8.55±0.19(Predicted)
• CAS DataBase Reference: 2-Boc-4-(2-pyridyl)hoMopiperazine, 95%(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Boc-4-(2-pyridyl)hoMopiperazine, 95%(632334-60-2)
• EPA Substance Registry System: 2-Boc-4-(2-pyridyl)hoMopiperazine, 95%(632334-60-2)

Safety Data

• Hazardous Substances Data: 632334-60-2(Hazardous Substances Data)

Upstream product

• 109-04-6 2-bromo-pyridine 
• 112275-50-0 tert-butyl 1,4-diazepine-1-carboxylate 

Downstream Products

• 287114-32-3 1-(2-pyridinyl)-1,4-diazepane 

Relevant articles and documents

Discovery and structure-activity relationship of thienopyridine derivatives as bone anabolic agents

A cell-based assay was performed for the discovery of novel bone anabolic agents. Alkaline phosphatase (ALPase) activity of ST2 cells was utilized as an indicator of osteoblastic differentiation, and thienopyridine derivative 1 was identified as a hit compound. 3-Aminothieno[2,3-b]pyridine-2-carboxamide was confirmed to be a necessary core structure for the enhancement of ALPase activity, and then optimization of the C4-substituent on the thienopyridine ring was carried out. Introduction of cyclic amino groups to the C4-position of the thienopyridine ring improved the activity. Especially, N-phenyl-homopiperazine derivatives were found to be strong enhancers of ALPase among this new series. Furthermore, 3-amino-4-(4-phenyl-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2- carboxamide (15k) was orally administered to ovariectomized (OVX) rats over 6 weeks for evaluating the effects on areal bone mineral density (aBMD), and statistically significant improvements in aBMD were observed from the dosage of 10 mg/kg/day.

An improved synthesis of N-aryl and N-heteroaryl substituted homopiperazines-from conventional thermal conditions to scaling-up using microwave heating

An efficient Pd(0)-catalyzed Buchwald-Hartwig protocol for the facile preparation of N-aryl and N-heteroaryl substituted homopiperazines is described. The syntheses proceeded with aryl- and heteroaryl halides in high yields using X-Phos as best ligand. Th

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