- PYRROLOPYRIDAZINE INHIBITORS OF IRAK4 ACTIVITY
-
The present invention relates to pyrrolopyridazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
- -
-
Page/Page column 41
(2016/09/26)
-
- SUBSTITUTED THIENOIMIDAZOLES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT OR DIAGNOSTIC AND MEDICAMENTS COMPRISING THE SAME
-
The invention relates to substituted thienoimidazoles of formula (I) or (II), where R1 to R4 have the meanings given in the claims. Medicaments comprising compounds of this type are useful for the prevention or treatment of diverse diseases. The compounds find application, amongst other things, for the treatment of breathing disorders and snoring, to improve the breathing process, for treatment of chronic and acute diseases of the kidney and the intestine, diseases caused by ischaemic and/or reperfusion events, proliferative or fibrotic diseases, for the treatment or prophylaxis of diseases of the central nervous system, lipometabolism, diabetes, blood clotting and parasitic attack.
- -
-
Page/Page column 34
(2010/02/11)
-
- Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis
-
Substituted thiophenes, processes for their preparation, their use as medicament or diagnostic agent. The substituted thiophene derivatives have the following backbone structure: Medicaments comprising compounds of this type are of use for preventing or treating various disorders, such as, respiratory disorders and snoring, acute and chronic disorders, disorders induced by ischemic and/or reperfusion events and by proliferative or fibrotic events, disorders of the central nervous system and lipid metabolism, diabetes, blood coagulation and infection by parasites.
- -
-
Page/Page column 24
(2008/06/13)
-