632356-42-4

Basic information

• Product Name: 4-CHLORO-3-THIOPHENAMINE
• Synonyms: 4-CHLORO-3-THIOPHENAMINE;4-chlorothiophen-3-aMine;3-ThiophenaMine, 4-chloro-;3-AMino-4-chlorothiophen;3-AMino-4-chlorothiophen HCl
• CAS NO: 632356-42-4
• Molecular Formula: C4H4ClNS
• Molecular Weight: 133.6
• Mol File: 632356-42-4.mol

Chemical Properties

• Boiling Point: 254.082 °C at 760 mmHg
• Flash Point: 107.465 °C
• Appearance: /
• Density: 1.434 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• PKA: 2.32±0.10(Predicted)
• CAS DataBase Reference: 4-CHLORO-3-THIOPHENAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-3-THIOPHENAMINE(632356-42-4)
• EPA Substance Registry System: 4-CHLORO-3-THIOPHENAMINE(632356-42-4)

Safety Data

• Hazardous Substances Data: 632356-42-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-3-thiophenamine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of drugs with specific therapeutic properties. It plays a crucial role in the production of drugs such as tipepidine and sulconazole, where its unique molecular structure imparts desired medicinal characteristics.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Chloro-3-thiophenamine serves as an intermediate in the creation of compounds that address various agricultural needs, including pest control and crop protection, leveraging its chemical reactivity and structural attributes to enhance the effectiveness of these products.
Used in Dye and Pigment Manufacturing:
4-Chloro-3-thiophenamine is utilized as an intermediate in the manufacture of dyes and pigments, capitalizing on its capacity to form colorants with specific properties. Its presence in these compounds contributes to the colorfastness and stability required in various applications, such as textiles, plastics, and printing inks.
It is important to handle 4-Chloro-3-thiophenamine with care due to its potential hazards. As a chemical with harmful properties, it can cause irritation to the skin and eyes and may be harmful if ingested or inhaled, necessitating proper safety measures during its use and disposal.

Upstream product

• 937637-29-1 tert-butyl (4-chlorothiophen-3-yl)carbamate 
• 632356-41-3 methyl 3-amino-4-chlorothiophene-2-carboxylate 

Relevant articles and documents

PYRROLOPYRIDAZINE INHIBITORS OF IRAK4 ACTIVITY

The present invention relates to pyrrolopyridazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.

SUBSTITUTED THIENOIMIDAZOLES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT OR DIAGNOSTIC AND MEDICAMENTS COMPRISING THE SAME

The invention relates to substituted thienoimidazoles of formula (I) or (II), where R1 to R4 have the meanings given in the claims. Medicaments comprising compounds of this type are useful for the prevention or treatment of diverse diseases. The compounds find application, amongst other things, for the treatment of breathing disorders and snoring, to improve the breathing process, for treatment of chronic and acute diseases of the kidney and the intestine, diseases caused by ischaemic and/or reperfusion events, proliferative or fibrotic diseases, for the treatment or prophylaxis of diseases of the central nervous system, lipometabolism, diabetes, blood clotting and parasitic attack.

Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis

Substituted thiophenes, processes for their preparation, their use as medicament or diagnostic agent. The substituted thiophene derivatives have the following backbone structure: Medicaments comprising compounds of this type are of use for preventing or treating various disorders, such as, respiratory disorders and snoring, acute and chronic disorders, disorders induced by ischemic and/or reperfusion events and by proliferative or fibrotic events, disorders of the central nervous system and lipid metabolism, diabetes, blood coagulation and infection by parasites.