Discovery of 4H-pyrazolo[1,5-a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase
A series of 4H-pyrazolo[1,5-a]pyrimidin-7-one derivatives was synthesized and evaluated for inhibitory activity against HCV NS5B RNA-dependent RNA polymerase. A number of these compounds exhibited potent activity in enzymatic assay. The synthesis and stru
Deng, Yongqi,Shipps Jr., Gerald W.,Wang, Tong,Popovici-Muller, Janeta,Rosner, Kristin E.,Siddiqui, M. Arshad,Duca, Jose,Cooper, Alan B.,Cable, Michael
scheme or table
p. 5363 - 5367
(2010/05/19)
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