Preparation method of poly-substitution 6-fluorine picolinic acid
The invention discloses a preparation method of poly-substitution 6-fluorine picolinic acid. The preparation method comprises the following steps: performing diazotization on the poly-substitution 2-amino-6-picoline and a diazotized agent; performing a reaction on a fluorinating agent to generate the poly-substitution 2-amino-6-fluoride pyridine; performing an oxidizing reaction on the poly-substitution 6-picoline-2-fluoride pyridine and an oxidizing agent to obtain the poly-substitution 6-fluorine picolinic acid. The invention provides a novel initial raw material for preparing poly-substitution 6-fluorine picolinic acid, and correspondingly provides a novel reaction path and process. The poly-substitution 2-amino-6-picoline is taken as the initial raw material has the advantages of low cost and readily-available; the prepared 6-fluorine picolinic acid has the advantages of simple process, low requirement on reaction conditions, high security performance, high product yield and purityand easiness in realizing scale production.
Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I)are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis
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(2008/06/13)
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