- A nitrogen hetero-cycloalkyl amino quinacridineone-4-amide compound and its preparation method and application
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The invention provides an azo-heteroaromatic cycloalkylaminoacridone-4-amide compound which is shown in a formula I or a formula II as shown in the specification, as well as a preparation method and application thereof. In the formula I and the formula II
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Paragraph 0206-0208
(2017/01/31)
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- Method for synthesizing N-o-carboxypnenyl-4-chloro-2-aminobenzoic acid serving as intermediate of lobenzarit medicine
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A method for synthesizing N-o-carboxypnenyl-4-chloro-2-aminobenzoic acid serving as an intermediate of a lobenzarit medicines includes steps: (i) adding 400ml of diethyl ether, 0.079mol of 2-amino-4-chlorod-benzoic acid (2), 0.016-0.018mol of o-aminobenzoic acid (3), 0.19-0.21mol of ethylenediamine and 3.8g of nickel powder into a reaction vessel with a stirrer, a temperature gauge and a dropping funnel, controlling a stirring speed to be 180-210rpm, enabling a reflux reaction to last for 8-9h, leaching, dissolving a filter cake into 500ml of a salt solution, performing molecular sieve decoloration, adding an oxalic acid solution, keeping a pH value of the solution at 5-6, precipitating solids, filtering, washing with a potassium chloride solution, and recrystallizing in methylamine to obtain light yellow solid N-o-carboxypnenyl-4-chloro-2-aminobenzoic acid. The diethyl ether refers to absolute diethyl ether, and the salt solution refers to either a copper sulfate solution or a ferric nitrate solution.
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Paragraph 0013; 0014
(2016/11/17)
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- Molecular design, synthesis and biological research of novel pyridyl acridones as potent DNA-binding and apoptosis-inducing agents
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A series of novel pyridyl acridone derivatives comprised of a pseudo-five-cyclic system to extend the π-conjugated acridone chromophore, were designed and synthesized as potent DNA binding antitumor compounds. Most synthesized compounds displayed good act
- Zhang, Bin,Chen, Kang,Wang, Ning,Gao, Chunmei,Sun, Qinsheng,Li, Lulu,Chen, Yuzong,Tan, Chunyan,Liu, Hongxia,Jiang, Yuyang
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supporting information
p. 214 - 226
(2015/03/04)
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- Design, synthesis and anti-inflammatory activity of structurally simple anthranilic acid congeners devoid of ulcerogenic side effects
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Simple, three classes of new anthranilic acid derivatives were aimed at, synthesized and tested for their toxicity, anti-inflammatory, analgesic, antipyretic activity. Also, their potential protective role against ulcerative colitis in rats was performed.
- Eissa, Amal Abdel Haleem Mohamed,Soliman, Gamal Abd El-Hakeem,Khataibeh, Moayad Hussein
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p. 1290 - 1300,11
(2020/09/14)
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- Potential antitumor agents. 38. 3-Substituted 5-carboxamido derivatives of amsacrine
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The synthesis and biological evaluation of a series of 3-substituted 5-carboxamido derivatives of amsacrine (m-AMSA) are described. This series was developed as the result of previous quantitative structure-activity relationship (QSAR) studies of the antitumor activity of 9-anilinoacridine derivatives. In agreement with these studies, this class of compounds, possessing a variety of small nonpolar groups at the 3-position, together with very hydrophilic carboxamido groups at the 5-position, have high in vivo activity against animal leukemia models.
- Denny,Atwell,Baguley
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p. 1619 - 1625
(2007/10/02)
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- Novel aminobenzoic acid derivatives, process for preparing the same and pharmaceutical composition containing the same
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An aminobenzoic acid derivative represented by the formula STR1 wherein R1, R2 and R3 are defined hereinbelow, which has excellent activity for improving liver function and for potentiating and normalizing immunity; a process for preparing the same; and a pharmaceutical composition containing the same are disclosed.
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