635313-65-4Relevant articles and documents
Production of anticancer polyenes through precursor-directed biosynthesis
Clark, Benjamin R.,O'Connor, Stephen,Fox, Deirdre,Leroy, Jacques,Murphy, Cormac D.
, p. 6306 - 6311 (2011/10/10)
The biosynthesis of the pyrrolyl moiety of the fungal metabolite rumbrin originates from pyrrole-2-carboxylic acid. In an effort to produce novel derivatives with enhanced biological activity a series of substituted pyrrole-2-carboxylates were synthesised
2-Aminobenzimidazoles as potent ITK antagonists: de novo design of a pyrrole system targeting additional hydrogen bonding interaction
Lo, Ho Yin,Bentzien, J?rg,White, Andre,Man, Chuk C.,Fleck, Roman W.,Pullen, Steven S.,Khine, Hnin Hnin,King, Josephine,Woska Jr., Joseph R.,Wolak, John P.,Kashem, Mohammed A.,Roth, Gregory P.,Takahashi, Hidenori
scheme or table, p. 7337 - 7340 (2009/04/14)
Based on information from molecular modeling, a series of 2-aminobenzimidazoles with pyrrole moieties were designed and synthesized as ITK antagonists. Results showed that a significant improvement of intrinsic and cell-based potency was achieved. X-ray c
Ring-deactivated hydroxyalkylpyrrole-based inhibitors of α-chymotrypsin: Synthesis and mechanism of action
Martyn, Derek C.,Vernall, Andrea J.,Clark, Bruce M.,Abell, Andrew D.
, p. 2103 - 2110 (2007/10/03)
13C NMR and mass spectrometry studies have been used to demonstrate that the inhibition of α-chymotrypsin by N-sulfonylhydroxymethylpyrrole inhibitors (10) is non-covalent. Hydroxyalkylpyrroles in which an electron-withdrawing group (acyl substituent) is introduced at the alternative C2 position have been synthesised and also shown to inactivate α-chymotrypsin. SAR studies on this class suggests that the incorporation of phenylalanine at C2 is favoured, however, there is little gain in introducing a hydrophobic substituent at C5.
