63624-28-2

Basic information

• Product Name: 2,4-DIMETHOXYBENZENESULFONYL CHLORIDE
• Synonyms: ART-CHEM-BB B019391;CHEMBRDG-BB 4006317;2,4-DIMETHOXYBENZENESULFONYL CHLORIDE;2,4-DIMETHOXYBENZENE SULPHONYL CHLORIDE;AKOS B019391;Benzenesulfonyl chloride, 2,4-dimethoxy- (9CI);2,4-dimethoxybenzenesulfonyl chloride(SALTDATA: FREE);2,4-DiMethoxyphenylsulfonyl chloride
• CAS NO: 63624-28-2
• Molecular Formula: C₈H₉ClO₄S
• Molecular Weight: 236.67
• Product Categories: SULFONYLHALIDE;Benzenesulfonyl chloride;Heterocyclic Compounds;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds
• Mol File: 63624-28-2.mol

Chemical Properties

• Melting Point: 69-71 °C
• Boiling Point: 363.6 °C at 760 mmHg
• Flash Point: 173.7 °C
• Appearance: powder
• Density: 1.359 g/cm³
• Vapor Pressure: 3.74E-05mmHg at 25°C
• Refractive Index: 1.522
• Storage Temp.: 2-8°C
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 2,4-DIMETHOXYBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHOXYBENZENESULFONYL CHLORIDE(63624-28-2)
• EPA Substance Registry System: 2,4-DIMETHOXYBENZENESULFONYL CHLORIDE(63624-28-2)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-43
• Safety Statements: 45-36/37/39-3-26
• RIDADR: 3261
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 63624-28-2(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C8H9ClO4S/c1-12-6-3-4-8(14(9,10)11)7(5-6)13-2/h3-5H,1-2H3

Upstream product

• 151-10-0 1,3-Dimethoxybenzene 

Downstream Products

• 169039-28-5 3-Amino-5-chloro-1,3-dihydro-1-(2,4-dimethoxybenzenesulfonyl)-3-phenylindol-2-one 
• 169039-30-9 3-amino-5-chloro-3-(2-chlorophenyl)-1-[(2,4-dimethoxyphenyl)sulphonyl]-1,3-dihydro-2H-indol-2-one 
• 169040-09-9 5-Ethoxy-3-(2-ethoxycarbonyl-1-ethoxycarbonylhydrazino)-1,3-dihydro-1-(2,4-dimethoxybenzenesulfonyl)-3-phenylindol-2-one 
• 169040-11-3 3-Amino-3-(2-chlorophenyl)-5-ethoxy-1,3-dihydro-1-(2,4-dimethoxybenzenesulfonyl)indol-2-one 
• 1170678-88-2 1-(2,4-Dimethoxyphenylsulfonyl)-3-(2-ethoxypyridin-3-yl)-3-hydroxy-5-iodo-1,3-dihydroindol-2-one 
• 1182402-94-3 tert-butyl 4-[3-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-fluoro-phenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propyl]piperidin-1-carboxylate 
• 1158627-44-1 2,4-dimethoxy-N-(5-ethyl-5H-γ-carbolin-8-yl)benzenesulfonamide 
• 1232007-56-5 2,4-dimethoxy-N-(quinolin-8-yl)benzenesulfonamide 
• 1234702-70-5 3-chloro-6-(2,4-dimethoxy-benzenesulfonyl)-6,7,8,9-tetrahydro-5H-dipyrido[2,3-b;3',4'-d]pyrrole 
• 947602-61-1 C₃₀H₃₂ClN₃O₈S 
• 439687-69-1 Nelivaptan 
• 1220017-28-6 C₂₆H₃₄N₂O₈S₂ 
• 492430-17-8 5-chloro-1-[(2,4-dimethoxyphenyl)sulphonyl]-1H-indole-2,3-dione 

Relevant articles and documents

Dihydroxyphenyl Sulfonylisoindoline Derivatives

Provided are compounds that are inhibitors of pyruvate dehydrogenase kinase (PDK), and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.

Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors

Pyruvate dehydrogenase kinases 1-4 (PDK1-4) negatively control activity of the pyruvate dehydrogenase complex (PDC) and are up-regulated in obesity, diabetes, heart failure, and cancer. We reported earlier two novel pan-PDK inhibitors PS8 [4-((5-hydroxyisoindolin-2-yl)sulfonyl)benzene-1,3-diol] (1) and PS10 [2-((2,4-dihydroxyphenyl)sulfonyl)isoindoline-4,6-diol] (2) that targeted the ATP-binding pocket in PDKs. Here, we developed a new generation of PDK inhibitors by extending the dihydroxyphenyl sulfonylisoindoline scaffold in 1 and 2 to the entrance region of the ATP-binding pocket in PDK2. The lead inhibitor (S)-3-amino-4-(4-((2-((2,4-dihydroxyphenyl)sulfonyl)isoindolin-5-yl)amino)piperidin-1-yl)-4-oxobutanamide (17) shows a ～8-fold lower IC50 (58 nM) than 2 (456 nM). In the crystal structure, the asparagine moiety in 17 provides additional interactions with Glu-262 from PDK2. Treatment of diet-induced obese mice with 17 resulted in significant liver-specific augmentation of PDC activity, accompanied by improved glucose tolerance and drastically reduced hepatic steatosis. These findings support 17 as a potential glucose-lowering therapeutic targeting liver for obesity and type 2 diabetes.

Novel 1,3-dihydro-2h-indol-2-one derivatives, method for preparing same and pharmaceutical compositions containing them

The invention relates to compounds of formula: and to solvates and/or hydrates thereof, with affinity for and selectivity towards the V1b receptors or both the V1b and V1a receptors of arginine-vasopressin. The invention also relates to a process for preparing them, to the intermediate compounds of formula (II) which are useful for preparing them, to pharmaceutical compositions containing them and to their use for preparing medicinal products.

N-substituted 2,4-dialkoxy benzenesulfonamides and pharmaceutical compositions

The invention relates to new N-substituted benzenesulfonamides, the process for their preparation and their use. The compounds according to the invention correspond to the general formula (I): STR1 in which: n and m have values from 0 to 4; R3 and R4 represent in particular a lower alkyl radical; R1 and R2 represent in particular hydrogen atoms, linear or branched alkyl groups having from 1 to 4 carbon atoms; R5 represents particularly a hydrogen atom, a halogen, the NO2, NH2, or CF3 group; R6 and R7 represent in particular a hydrogen atom, an alkyl radical of 1 to 6 carbon atoms. The invention is useful in the preparation of tranquilizing or anxiolytic medicines.

Monomethylthio analogues of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane

Regiospecific syntheses of the three monomethylthio analogues of 1-(2,4,5- trimethoxyphenyl)-2-aminopropane are described. The three isomeric amines were evaluated for potential psychotomimetic potency using the rabbit hyperthermia assay. Enantiomeric com