637027-24-8

Basic information

• Product Name: (R)-1,4-di-Boc-piperazine-2-carboxylic acid Methyl ester
• Synonyms: (R)-1,4-di-Boc-piperazine-2-carboxylic acid Methyl ester;1,2,4-Piperazinetricarboxylic acid, 1,4-bis(1,1-diMethylethyl) 2-Methyl ester, (2R)-;(R)-1,4-Di-tert-butyl 2-Methyl piperazine-1,2,4-tricarboxylate
• CAS NO: 637027-24-8
• Molecular Formula: C₁₆H₂₈N₂O₆
• Molecular Weight: 344.40332
• Mol File: 637027-24-8.mol

Chemical Properties

• Boiling Point: 406.6±40.0 °C(Predicted)
• Appearance: /
• Density: 1.145±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -0.27±0.70(Predicted)
• CAS DataBase Reference: (R)-1,4-di-Boc-piperazine-2-carboxylic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1,4-di-Boc-piperazine-2-carboxylic acid Methyl ester(637027-24-8)
• EPA Substance Registry System: (R)-1,4-di-Boc-piperazine-2-carboxylic acid Methyl ester(637027-24-8)

Safety Data

• Hazardous Substances Data: 637027-24-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R)-1,4-di-Boc-piperazine-2-carboxylic acid Methyl ester is used as a key intermediate in the synthesis of various drug candidates and molecules with biological activity. Its unique chemical composition and function enable the creation of cutting-edge pharmaceutical compounds, playing a crucial role in the development of new medications and treatments for a wide range of medical conditions.
Used in Organic Synthesis:
In the field of organic synthesis, (R)-1,4-di-Boc-piperazine-2-carboxylic acid Methyl ester is employed as a versatile building block for the preparation of complex organic molecules. Its reactivity and structural features allow chemists to construct a variety of compounds with potential applications in different industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 173774-48-6 (R)-piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester 
• 74-88-4 methyl iodide 
• 279227-92-8 (R)-1-N-Boc-piperazine-2-carboxylic acid methyl ester hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 252990-05-9 1-(tert-butyl) 2-methyl (R)-piperazine-1,2-dicarboxylate 

Downstream Products

• 173774-48-6 (R)-piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester 
• 1589081-62-8 (R)-2-benzoylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester 
• 1589081-63-9 (R)-2-(hydroxyphenylmethyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester 
• 1589081-64-0 (R)-2-(fluorophenylmethyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester 
• 1589081-66-2 (R)-2-(4-fluorobenzoyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester 
• 1589081-67-3 (R)-2-[(4-fluorophenyl)hydroxymethyl]piperazine-1,4-dicarboxylic acid di-tert-butyl ester 

Relevant articles and documents

ANTAGONISTS OF THE ADENOSINE A2A RECEPTOR

The present invention relates to compounds of formula I shown below: wherein R0, R1, R2, R3 and A are each as defined in the application. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or conditions in which adenosine A2a receptor activity is implicated, such as, for example, cancer.

AZAQUINAZOLINE INHIBITORS OF ATYPICAL PROTEIN KINASE C

The present invention provides a compound of formula (I) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. A compound of formula (I) and its salts have a PKC inhibitory activity, and may be used to treat proliferative disorders.

Human Adam-10 Inhibitors

Magnesium salts/complexes of compounds useful for inhibiting the ADAM-IO protein and methods of making and purifying them are provided. Further provided are compositions comprising magnesium salts/complexes of the compounds in combination with a pharmaceutically acceptable carrier. The compounds well as such compositions comprising them are useful for the treatment of cancer, arthritis, diseases related to angiogenesis, such as renal diseases, heart diseases, such as heart failure, atherosclerosis, and stroke, inflammation, ulcer, infertility, scleroderma, endometriosis, mesothelioma, and diabetes. In addition, methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role are provided.

HUMAN ADAM-10 INHIBITORS

The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.