638197-51-0

Basic information

• Product Name: 1-(6-Bromopyridin-2-yl)-3-(dimethylamino)prop-2-en-1-one
• Synonyms: 1-(6-Bromopyridin-2-yl)-3-(dimethylamino)prop-2-en-1-one;(E)-1-(6-bromopyridin-2-yl)-3-(dimethylamino)prop-2-en-1-one
• CAS NO: 638197-51-0
• Molecular Formula: C10H11BrN2O
• Molecular Weight: 255.11114
• Mol File: 638197-51-0.mol

Chemical Properties

• Melting Point: 122～124℃
• Boiling Point: 345.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.411±0.06 g/cm3(Predicted)
• PKA: 4.62±0.70(Predicted)
• CAS DataBase Reference: 1-(6-Bromopyridin-2-yl)-3-(dimethylamino)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-Bromopyridin-2-yl)-3-(dimethylamino)prop-2-en-1-one(638197-51-0)
• EPA Substance Registry System: 1-(6-Bromopyridin-2-yl)-3-(dimethylamino)prop-2-en-1-one(638197-51-0)

Safety Data

• Hazardous Substances Data: 638197-51-0(Hazardous Substances Data)

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.

Explanation

The color and physical state of the compound, which can be useful for identification and handling purposes.

Explanation

The compound belongs to a class of chemical compounds derived from pyridine, a six-membered aromatic ring containing one nitrogen atom.

Explanation

The presence of a bromine atom attached to the 6th position of the pyridine ring, which can influence the compound's reactivity and properties.

Explanation

A part of the molecule that consists of a carbonyl group (C=O) and a carbon-carbon double bond (C=C), which can participate in various chemical reactions.

Explanation

A nitrogen atom bonded to two methyl groups (CH3) attached to the 3rd position of the propenone moiety, which can affect the compound's polarity and reactivity.

Explanation

The various potential uses of the compound in different fields, highlighting its versatility and importance in chemical and medicinal research.

Explanation

The solubility of the compound in different solvents is not mentioned, which is an important property for its handling and use in chemical reactions.

Explanation

The stability of the compound under various conditions (e.g., temperature, light, moisture) is not mentioned, which is crucial for its storage and use in research and development.

Explanation

The potential toxicity of the compound is not mentioned, which is an important consideration for its use in research and development, especially in pharmaceutical applications.

Appearance

Yellow solid

Chemical class

Pyridine derivative

Bromine substituent

At the 6 position

Propenone moiety

Contains a carbonyl group and a double bond

Dimethylamino group

At the 3 position

Applications

Organic synthesis, pharmaceutical research, building block for biologically active compounds, reagent in chemical reactions, and component in drug/material development

Upstream product

• 626-05-1 2,6-Dibromopyridine 
• 49669-13-8 1-(6-bromopyridin-2-yl)-ethanone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Relevant articles and documents

Anionically Substituted 1,1′,l″-Methylidynetris[1H-pyrazole] Ligands for the Formation of Neutral Lanthanide Complexes in Water: Synthesis, Characterization, and Photophysical Properties

The six-step synthesis of the new podand-type ligand 6,6′,6″ -[methylidenetri(1H-pyrazole-1,3-diyl)]tris-[pyridine-2-carboxylic acid] (LH3) is described. Reaction of LH3 with LnCl 3·6 H2O (Ln = Eu, Gd, Tb) in MeOH resulted in the isolation of [LnL]·HCl complexes characterized by elemental analysis, mass and IR spectroscopy. Photophysical studies of the Eu and Tb complexes in aqueous solutions revealed the characteristic luminescence features of the metal atoms, indicative of an efficient ligand-to-metal energy-transfer process. Determination of the luminescence quantum yields in H2O showed the Tb complex to be highly luminescent (φ = 15%), while, for the Eu complex, the quantum efficiency was only 2%. Excited-state-lifetime measurements in H2O and D2O evidenced the presence of ca. three H 2O molecules in the first coordination sphere of the complexes. Investigation of the Gd complex allowed the determination of the ligand-centered triplet state and showed the ligand to be well suited for energy transfer to the metal. The luminescence properties of the complexes are described, and the properties of the ligand as a suitable complexation pocket is questioned.

OXAZOLIDINONE COMPOUNDS AND THEIR USES IN PREPARATION OF ANTIBIOTICS

The invention belongs to the field of medicaments, and particularly relates to oxazolidinone compounds and their uses in the preparation of antibiotics. A technical problem to be solved by the invention is to provide new oxazolidinone compounds having the structure represented by Formula I. The oxazolidinone compounds of the invention, which are new compounds obtained through numerous screening, have significant antibacterial activity against bacteria such as drug-resistant staphylococcus aureus, fecal coliform bacteria, and streptococcus pneumoniae, while exhibiting low toxicity. The invention provides new options for the development and application of antibiotics.

A convenient preparative method for anionic tris(substituted pyrazolyl)methane ligands

The synthesis of tris[3-(6-carboxypyridin-2-yl)pyrazol-1-yl]methane is described in a linear multi-step protocol. The pyridyl-pyrazolyl arms are first constructed before being condensed with chloroform. Careful study of the condensation reaction shows the presence of an isomeric form of the tris(pyrazolyl)methane derivative in which one of the pyrazolyl substituents is linked through the nitrogen atom at the 2 position of the pyrazol. After acid-catalysed isomerisation to the desired isomer, the intermediate compound was subjected to a carboalkoxylation reaction and a subsequent hydrolysis. These are some rare examples of reactions directly occurring on the tris(pyrazolyl)methane platforms.