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6-METHYL-CHROMAN-4-YLAMINE, also known as 4-Amino-6-methylchromane, is a chemical compound with the molecular formula C10H13NO. It is a substituted chroman amine derivative known for its potential antioxidant and radical scavenging properties. 6-METHYL-CHROMAN-4-YLAMINE has garnered interest in the pharmaceutical and food industries due to its ability to inhibit oxidation processes and prevent the formation of free radicals. Furthermore, 6-Methyl-chroman-4-ylamine has demonstrated promising neuroprotective and anti-inflammatory properties, positioning it as a potential candidate for the development of new drugs targeting oxidative stress-related conditions and diseases.

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  • 638220-39-0 Structure
  • Basic information

    1. Product Name: 6-METHYL-CHROMAN-4-YLAMINE
    2. Synonyms: 6-METHYL-CHROMAN-4-YLAMINE;6-methylchroman-4-amine;2H-1-Benzopyran-4-amine, 3,4-dihydro-6-methyl-;6-methyl-3,4-dihydro-2H-chromen-4-ylamine hydrochloride;3,4-Dihydro-6-methyl-2H-1-benzopyran-4-amine;6-Methyl-3,4-dihydro-2H-chroMen-4-aMine
    3. CAS NO:638220-39-0
    4. Molecular Formula: C10H13NO
    5. Molecular Weight: 163.22
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 638220-39-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 256℃
    3. Flash Point: 110℃
    4. Appearance: /
    5. Density: 1.079
    6. Vapor Pressure: 0.016mmHg at 25°C
    7. Refractive Index: 1.553
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. PKA: 8.84±0.20(Predicted)
    11. CAS DataBase Reference: 6-METHYL-CHROMAN-4-YLAMINE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 6-METHYL-CHROMAN-4-YLAMINE(638220-39-0)
    13. EPA Substance Registry System: 6-METHYL-CHROMAN-4-YLAMINE(638220-39-0)
  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 638220-39-0(Hazardous Substances Data)

638220-39-0 Usage

Uses

Used in Pharmaceutical Industry:
6-METHYL-CHROMAN-4-YLAMINE is used as a pharmaceutical candidate for its neuroprotective and anti-inflammatory properties, making it suitable for the development of new drugs targeting oxidative stress-related conditions and diseases.
Used in Food Industry:
6-METHYL-CHROMAN-4-YLAMINE is used as an antioxidant and radical scavenger to inhibit oxidation processes and prevent the formation of free radicals, thereby enhancing the shelf life and quality of food products.
Used in Antioxidant Applications:
6-METHYL-CHROMAN-4-YLAMINE is used as an antioxidant agent for its ability to inhibit oxidation processes, which can help protect cells and tissues from oxidative damage and reduce the risk of various diseases associated with oxidative stress.
Used in Neuroprotective Applications:
6-METHYL-CHROMAN-4-YLAMINE is used as a neuroprotective agent for its potential to protect neurons from oxidative damage and inflammation, making it a promising candidate for the treatment of neurodegenerative diseases.
Used in Anti-Inflammatory Applications:
6-METHYL-CHROMAN-4-YLAMINE is used as an anti-inflammatory agent for its ability to reduce inflammation and oxidative stress, which can be beneficial in the treatment of various inflammatory conditions and diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 638220-39-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,3,8,2,2 and 0 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 638220-39:
(8*6)+(7*3)+(6*8)+(5*2)+(4*2)+(3*0)+(2*3)+(1*9)=150
150 % 10 = 0
So 638220-39-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H13NO/c1-7-2-3-10-8(6-7)9(11)4-5-12-10/h2-3,6,9H,4-5,11H2,1H3

638220-39-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-Methylchroman-4-amine

1.2 Other means of identification

Product number -
Other names 6-methyl-3,4-dihydro-2H-chromen-4-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:638220-39-0 SDS

638220-39-0Downstream Products

638220-39-0Relevant articles and documents

Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists

Schmidt, Robert G.,Bayburt, Erol K.,Latshaw, Steven P.,Koenig, John R.,Daanen, Jerome F.,McDonald, Heath A.,Bianchi, Bruce R.,Zhong, Chengmin,Joshi, Shailen,Honore, Prisca,Marsh, Kennan C.,Lee, Chih-Hung,Faltynek, Connie R.,Gomtsyan, Arthur

scheme or table, p. 1338 - 1341 (2011/04/23)

Novel chroman and tetrahydroquinoline ureas were synthesized and evaluated for their activity as TRPV1 antagonists. It was found that aryl substituents on the 7- or 8-position of both bicyclic scaffolds imparted the best in vitro potency at TRPV1. The most potent chroman ureas were assessed in chronic and acute pain models, and compounds with the ability to cross the blood-brain barrier were shown to be highly efficacious. The tetrahydroquinoline ureas were found to be potent CYP3A4 inhibitors, but replacement of bulky substituents at the nitrogen atom of the tetrahydroisoquinoline moiety with small groups such as methyl can minimize the inhibition.

ANTAGONISTS OF THE TRPV1 RECEPTOR AND USES THEREOF

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Page/Page column 19, (2008/12/06)

The present application is directed to compounds that are TRPV1 antagonists and have formula (I) wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2, and Y3, are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.

8-SUBSTITUTED 2-(BENZIMIDAZOLYL)PURINE DERIVATIVES FOR IMMUNOSUPPRESSION

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Page/Page column 9, (2008/06/13)

The present invention provides novel purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formula I:

7-Substituted Purine Derivatives for Immunosuppression

-

Page/Page column 31, (2008/12/05)

The present invention provides novel purinone and related derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formula III:

Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof

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Page/Page column 13, (2008/06/13)

Compounds that are antagonists of the VR1 receptor, having formula (I) [image] or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R7, R8, R9, X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.

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