63895-62-5 Usage
Uses
Used in Pharmaceutical Industry:
(6-bromo-thieno[2,3-d]pyrimidin-4-yl)-(1-phenyl-ethyl)-amine is used as a potential ligand or molecular scaffold for the development of new bioactive compounds. Its unique structure allows it to be a valuable tool in the creation of various pharmaceuticals, such as kinase inhibitors and antiviral agents.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (6-bromo-thieno[2,3-d]pyrimidin-4-yl)-(1-phenyl-ethyl)-amine is used for the design and synthesis of novel compounds with potential pharmacological activities. Its versatile structure enables researchers to explore a wide range of biological effects and applications.
Used in Drug Development:
(6-bromo-thieno[2,3-d]pyrimidin-4-yl)-(1-phenyl-ethyl)-amine is employed in drug development as a starting point for creating new pharmaceuticals. Its unique structural features make it an attractive candidate for the development of targeted therapies and other advanced treatments.
Used in Kinase Inhibitor Design:
(6-broMo-thieno[2,3-d]pyriMidin-4-yl)-(1-phenyl-ethyl)-aMine is used as a building block in the design of kinase inhibitors, which are important in the treatment of various diseases, including cancer and inflammatory disorders. Its structure allows for the development of selective and potent inhibitors that can modulate cellular signaling pathways.
Used in Antiviral Agent Development:
(6-bromo-thieno[2,3-d]pyrimidin-4-yl)-(1-phenyl-ethyl)-amine is also used in the development of antiviral agents, where its unique structure can potentially be exploited to target specific viral proteins or processes, leading to the inhibition of viral replication and the treatment of viral infections.
Check Digit Verification of cas no
The CAS Registry Mumber 63895-62-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,8,9 and 5 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 63895-62:
(7*6)+(6*3)+(5*8)+(4*9)+(3*5)+(2*6)+(1*2)=165
165 % 10 = 5
So 63895-62-5 is a valid CAS Registry Number.
63895-62-5Relevant articles and documents
Truncated structures used in search for new lead compounds and in a retrospective analysis of thienopyrimidine-based EGFR inhibitors
Bugge, Steffen,Moen, Ingri Ullestad,Kragseth Sylte, Kent-Ove,Sundby, Eirik,Hoff, B?rd Helge
, p. 175 - 194 (2015/03/18)
An approach for optimization of epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors using truncated thienopyrimidine structures combined with enzymatic assay has been evaluated. This was done by synthesis and EGFR activity measurement of a series of fragment structures and their corresponding drug-model analogues. On average, the activity of the drug-like structures increased a ten-fold as compared to the fragments. However, the potency of the drug-model compound could not be precisely predicted, visualising the typical challenge with linking substructures. Additionally, the activity data provided useful SAR information with respect to stereochemical preference and the structure requirements of the 4-amino group. A retrospective evaluation of binding efficiency in previously discovered thieno[2,3-d]pyrimidines, suggests a high probability of obtaining potent EGFR inhibitors if based on the 3-chloro-4-fluoroaniline moiety. Compounds derived from (S)-2-hydroxy-1-phenylethylamine also have resulted in highly active EGFR-TK inhibitors. In contrast the 3-ethynylaniline containing structures appears more difficult to develop. Thieno[2,3-d]pyrimidin-4-amines have also been used for construction of irreversible EGFR-TK inhibitors. The data indicate these compounds to possess sub-optimal non-covalent interactions.
