63905-73-7

Basic information

• Product Name: 1,2,3,4-Tetrahydro-isoquinolin-6-ol Hydrochloride
• Synonyms: 1,2,3,4-Tetrahydro-isoquinolin-6-ol Hydrochloride;6-Hydroxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride;1,2,3,4-Tetrahydro-6-isoquinolinol hydrochloride
• CAS NO: 63905-73-7
• Molecular Formula: C₉H₁₁NO*ClH
• Molecular Weight: 185.65068
• EINECS: -0
• Mol File: 63905-73-7.mol

Chemical Properties

• Melting Point: 222-224℃
• Boiling Point: 313.5°Cat760mmHg
• Flash Point: 169.5°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.000269mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 1,2,3,4-Tetrahydro-isoquinolin-6-ol Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-Tetrahydro-isoquinolin-6-ol Hydrochloride(63905-73-7)
• EPA Substance Registry System: 1,2,3,4-Tetrahydro-isoquinolin-6-ol Hydrochloride(63905-73-7)

Safety Data

• Hazardous Substances Data: 63905-73-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,2,3,4-Tetrahydro-isoquinolin-6-ol Hydrochloride is used as a precursor in the synthesis of various pharmaceuticals for its potential therapeutic applications in treating neurological disorders. Its ability to modulate neurotransmission and exhibit neuroprotective effects makes it a promising candidate for drug development in this field.
Used in Research and Development:
THIQ hydrochloride is used as a research compound in the field of neuroscience and neuropharmacology. It aids in the investigation of the mechanisms underlying neurological disorders and the development of novel therapeutic agents.
Used in Chemical Production:
1,2,3,4-Tetrahydro-isoquinolin-6-ol Hydrochloride is used in the production of other chemical derivatives, contributing to the synthesis of a wide range of organic compounds.
Used in Chemical Databases and Research Catalogs:
THIQ hydrochloride is listed in various chemical databases and research catalogs, providing researchers with access to its chemical properties and potential applications in scientific research and drug development.

InChI:InChI=1/C9H11NO.ClH/c11-9-2-1-8-6-10-4-3-7(8)5-9;/h1-2,5,10-11H,3-4,6H2;1H

Upstream product

• 42923-77-3 6-methoxy-1,2,3,4-tetrahydro-isoquinoline 
• 50-00-0 formaldehyd 
• 3458-98-8 3-hydroxyphenylethylamine hydrochloride 

Downstream Products

• 158984-83-9 N-tert-butoxycarbonyl-6-hydroxy-1,2,3,4-tetrahydroisoquinoline 
• 158984-84-0 6-trifluoromethanesulfonyloxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 170097-66-2 3,4-Dihydro-1H-isoquinoline-2.6-dicarboxylic acid 2-tert-butyl ester-6-methyl ester 
• 170097-67-3 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 
• 14446-24-3 6-hydroxy-1,2,3,4-tetrahydroisoquinoline 
• 1266120-56-2 6-(4-tert-butyl-cyclohexyloxy)-1,2,3,4-tetrahydro-isoquinoline hydrochloride 
• 1266120-58-4 3-tert-butoxycarbonylamino-4-[6-(4-tert-butyl-cyclohexyloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-4-oxo-butyric acid tert-butyl ester 
• 1266120-54-0 6-(4-tert-butyl-cyclohexyloxy)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 1184745-95-6 (S)-isopropyl6-(1-(4-(methylsulfonyl)phenyl)pyrrolidin-3-yloxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1184745-98-9 (S)-isopropyl6-(1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-yloxy)-3,4-dihydroisoquinorine-2(1H)-carboxylate 

Relevant articles and documents

Exploration of the linkage elements of porcupine antagonists led to potent Wnt signaling pathway inhibitors

The Wnt signaling pathway is a pivotal developmental pathway. It operates through control of cellular functions such as proliferation, differentiation, migration and polarity. Aberrant Wnt signaling has been implicated in the formation and metastasis of tumors. Porcupine is a component of the Wnt signaling pathway. It is a member of the membrane-bound O-acyltransferase family of proteins. Porcupine catalyzes the palmitoylation of Wnt proteins, a process which is essential to their secretion and activity. Here we report a novel series of compounds obtained by a scaffold hybridization strategy from two known porcupine inhibitor classes. The leading compound 62 demonstrated subnanomolar (IC50 0.11 nM) inhibition of Wnt signaling in a paracrine cellular reporter gene assay. Compound 62 also potently inhibited Wnt secretion into culture medium, an indication of direct inhibition of the porcupine protein. Furthermore, compound 62 showed excellent chemical, plasma and liver microsomal stabilities. Collectively, these results strongly support further optimization of this novel scaffold to develop better Wnt pathway inhibitors.

COMPOUND HAVING S1P RECEPTOR BINDING POTENCY AND USE THEREOF

Provided are: a compound represented by formula (I): (wherein ring A and ring D each represent a cyclic group which may have a substituent(s); E and G each represent a bond or a spacer having 1 to 8 atoms in its main chain; L represents a hydrogen atom or a substituent; X represents amino which may have a substituent(s), or a heterocylcic group which contains at least one nitrogen atom and which may have a substituent(s); n represents 0 to 3, in which when n is 2 or more, a plurality of ring A's may be the same or different from one another); a salt thereof; an N-oxide form thereof; a solvate thereof; a prodrug thereof; and a medicament which includes those. The compound represented by formula (I) is capable of binding S1P receptors (in particular, EDG-1 and/or EDG-6), and useful for preventing and/or treating rejection in transplantation, autoimmune diseases, allergic diseases, etc.

Sulfonyl derivatives

Sulfonyl derivatives represented by general formula (I), salts of the same, and solvates of both: and application of them as drugs: [wherein R1is hydrogen, hydroxyl, nitro or the like; R2and R3are each independently hydrogen, halogeno or the like; R4and R5are each dependently hydrogen, halogeno or the like; Q1is an optionally substituted saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group or the like; Q2is a single bond, oxygen or the like; Q3is, e.g., a group represented by formula (a): T1is carbonyl or the like; and X1and X2are each independently methylidyne or nitrogen]. These compounds exhibit potent Fxa inhibiting activities and serve as excellent anticoagulants which speedily exert satisfactory and persistent anti-thrombotic effects through oral administration and little cause adverse effects.