cas 6398-50-1, 1-Cyano-6-methoxy-3,4-dihydronaphtalene

Articles about 6398-50-1Total 13 be found

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Enantioselective catalytic fluorinative aza-semipinacol rearrangement
An efficient and highly stereoselective fluorinative aza-semipinacol rearrangement is described. The catalytic reaction requires use of Selectfluor in combination with the chiral, enantiopure phosphate anion derived from acid L3. Under optimized condition
Romanov-Michailidis, Fedor,Pupier, Marion,Besnard, Cline,Bürgi, Thomas,Alexakis, Alexandre
p. 4988 - 4991
(2014)
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Enantioselective synthesis of (-)-methoxyestrone
Enantioselective synthesis of unnatural (-)-methoxyestrone in 12 steps from the commercially available tetralone based on the formation of a chiral bicyclic intermediate having the A-B steroid ring framework was accomplished. The crucial synthetic step co
Betik, Robert,Kotora, Martin
p. 3279 - 3282
(2011)
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Suzuki-Miyaura cross-coupling reaction of naphthyl triflate with indole boronic acids catalyzed by a recyclable polymer-supported N-heterocyclic carbene-palladium complex catalyst: Synthesis of naphthalene-linked bis-heterocycles
In this study, the Suzuki-Miyaura cross-coupling reaction of naphthyl triflate with indole boronic acids catalyzed by a recyclable polymer-supported Pd-NHC complex catalyst is presented. The polymer-supported catalyst can be reused several times retaining high activity for the transformation. The structures of all the synthesized compounds were established by elemental analysis and from their mass, 1H-NMR, and 13C-NMR spectra.
Reddy, P. Aravinda,Reddy, A. Babul,Reddy, G. Ramachandra,Reddy, N. Subbarami
p. 1451 - 1456
(2014/01/06)

Structure-activity studies for a novel series of N-(arylethyl)-N- (1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamines possessing dual 5- HT uptake inhibiting and α2-antagonistic activities
In search of an α2-antagonist/5-HT uptake inhibitor as a potential new class of antidepressant with a more rapid onset of action, compound 3 was prepared and observed to possess high affinity for the α2-receptor (K(i) = 6.71 nM) and
Meyer, Michael D.,Hancock, Arthur A.,Tietje, Karin,Sippy, Kevin B.,Prasad, Rajnandan,Stout, David M.,Arendsen, David L.,Donner, B. Greg,Carroll, William A.
p. 1049 - 1062
(2007/10/03)

Synthesis of 2-tetralones via a novel 1,2-carbonyl transposition of 1-tetralones
Simple acidic hydrolysis of epoxyamides 4, derived from 1-tetralones, furnishes the corresponding 2-tetralones in good yield.
Pryde, David C.,Henry, Steven S.,Meyers
p. 3243 - 3246
(2007/10/03)

Photoexcited proton transfer from enhanced photoacids
Naphthols with electron-withdrawing groups such as cyano or methanesulfonyl at C-5 and C-8 exhibit greatly enhanced photoacidity. This increase in photoacidity enables the substituted naphthols to undergo excited-state proton transfer (ESPT) in alcohols and Me2SO in the absence of water. In aqueous tetrahydrofuran solution, efficient proton transfer to water occurs at much lower water concentrations than with the parent naphthol, and the kinetics of proton transfer indicate that a smaller water cluster is involved.
Tolbert, Laren M.,Haubrich, Jeanne E.
p. 10593 - 10600
(2007/10/02)

BIOGENIC AMINE UPTAKE INHIBITORS
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(2008/06/13)

Biogentic amine uptake inhibitors
Compounds of the formula: STR1 or a pharmaceutically acceptable salt thereof, wherein m is 0, 1 or 2 and n is 0 or 1; R1 is hydrogen or lower alkyl; R2 is C1 -C6 -alkyl substituted with a heterocyclic group or C7 -C16 -arylalkyl, wherein the aryl group is unsubstituted or substituted with from one to three non-hydrogen members independently selected from the group consisting of halogen, C1 -C6 -alkyl, halo-C1 -C6 -alkyl, C1 -C6 -alkoxy, hydroxy, amino and C1 -C6 -alkylamino; R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen, C1 -C6 -alkoxy, C1 -C6 -alkyl, halogen, and halo-C1 -C6 -alkyl, or any two of R3, R4, R5 and R6 taken together form a methylenedioxy group; and R7 is hydrogen or C1 -C6 -alkyl. These compounds are useful as inhibitors of the neuronal uptake of biogenic amines and for the treatment of affective disorders, such as, for example, depression.
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(2008/06/13)

1-AMINOMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENES
Compounds of the formula STR1 and pharmaceutically acceptable salt thereof, wherein R 2 is selected from hydroxy and lower alkoxy, R 5 is lower alkyl, and R 11 and R 12 are independently selected from hydrogen, halo, hydroxy, methoxy, and lower alkyl, are selective . alpha.. sub.2 adrenergic receptor antagonists useful in the treatment of glaucoma.
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(2008/06/13)

1-aminomethyl-1,2,3,4-tetrahydronaphthalenes
The present invention provides compounds of the formula STR1 or a pharmaceutically acceptable salt thereof wherein R1 is selected from hydrogen, halo, lower alkyl, lower alkoxy, or thioalkoxy; and R2 is lower alkoxy; or R1 and R2 together form a methylenedioxy or ethylenedioxy ring; R3 and R4 are independently selected from hydrogen, hydroxy, lower alkyl, lower alkoxy, lower alkylthio, (lower alkyl)amino, (lower alkylsulfonyl)amino, and halo; and R7 is selected from the group consisting of 2- or 3-thienyl, 2- or 3-furyl, and STR2 where R13 and R14 are independently selected from the group consisting of hydrogen, hydroxy, halogen, amino, lower alkyl, lower alkoxy, lower alkylthio, methylenedioxy, or ethylenedioxy. The compounds of the present invention selectively inhibit α2 -adrenergic receptors as well as inhibit the uptake of biogenic amines and are thus useful in the treatment of certain cardiovascular and psychiatric disorders.
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(2008/06/13)

Benzylic Cyanation via Oxidation and Simultaneous Nucleophilic Substitution
Use of dichlorodicyano benzoquinone and trimethylsilyl cyanide in suitable solvent permits the direct and ready transformation of benzylic C-H bonds to C-CN bonds with high yield and selectivity via oxidation and simultaneous nucleophilic substitution.
Lemaire, Marc,Doussot, Joel,Guy, Alain
p. 1581 - 1584
(2007/10/02)

Substituted cyanonaphthalene process
6-Alkoxy-5-halo-1-cyanonaphthalenes, useful as pharmaceutical intermediates, are prepared by (1) reacting a 6-alkoxytetralone with cyanide ion and a Lewis acid in a nitroalkane or nitroarene solvent to form a 6-alkoxy-1-cyano-3,4-dihydronaphthalene, (2) intimately mixing the resultant solution with an aqueous base selected from alkali metal, alkaline earth metal, and tetraalkylammonium hydroxides, alkoxides, carbonates, and bicarbonates to aromatize the 6-alkoxy-1-cyano-3,4-dihydronaphthalene, and (3) halogenating the resultant 6-alkoxy-1-cyanonaphthalene while still in the nitroalkane or nitroarene solvent.
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(2008/06/13)

TETRAHYDRO-6,7-DIMETHOXY-1H-BENZ[E]ISOINODOLINES USEFUL IN THE TREATMENT OF HYPERTENSION AND AS SEDATIVES
Disclosed herein are tetrahydro-benzo e!isoindolines represented by the formula STR1 wherein R, R 1 and R 2 are independently selected from hydrogen, loweralkyl of 1 to 4 carbon atoms, hydroxy, loweralkoxy of 1 to 3 carbon atoms, allyloxy, benzyloxy, benzoyloxy, thiomethyl, halo, STR2 wherein t is 0 or 1, n is 0 to 5 and R 11 and R 14 are independently selected from hydrogen, halo, hydroxy, loweralkyl of 1 to 4 carbon atoms, loweralkoxy of 1 to 3 carbon atoms or amino; orR and R. sub.1, or R 1 and R 2 can be taken together to form a methylenedioxy or ethylenedioxy bridge; with the proviso that at least one of R, R 1 or R 2 must be other than hydrogen and the proviso that two of R, R 1, or R 2 must be other than methoxy in the 7 and 8 positions when the remaining one of R, R 1 or R 2 is hydrogen; andR 3 is hydrogen, loweralkyl of 1 to 4 carbon atoms, halo-substituted loweralkyl of 1 to 4 carbon atoms, amino-substituted loweralkyl of 1 to 4 carbon atoms, amino-substituted arylalkyl, allyl, thioloweralkyl, loweralkanol, or STR3 wherein R 12 and R 13 are independently selected from hydrogen, hydroxy, amino, loweralkoxy of 1 to 3 carbon atoms and s is 1 to 3; or STR4 wherein m is 0, 1 or 2, p is 0 or 1, R 7 is hydrogen or loweralkyl of 1 to 4 carbon atoms and R 8 and R 9 are independently selected from hydrogen, hydroxy, methoxy, loweralkyl of 1 to 4 carbon atoms, or halo, or R 8 and R 9 can be taken together to form a methylenedioxy or ethylenedioxy bridge; or 1,4-benzodioxan of the formula STR5 wherein q is 1, 2 or 3, and R 10 is hydrogen, methoxy, amino, or halo; and the pharmaceutically acceptable salts thereof.
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(2008/06/13)