- 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF M4 MUSCARINIC ACETYLCHOLINE RECEPTOR
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Provided are cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor, compositions comprising said compounds, and uses of said compounds in the treatment or prevention of diseases in which M4 muscarinic acetylcholine receptors are involved, especially neurological and psychiatric disorders and diseases.
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Page/Page column 110-111
(2020/05/28)
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- Solvent-free synthesis of alkyl and fluoroalkyl sulfonium salts from sulfides and fluoroalkyl trifluoromethanesulfonates
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A series of diaryl(fluoroalkyl)sulfonium salts were synthesized from electron-rich diaryl sulfides and fluoroalkyl trifluoromethanesulfonates under solvent-free conditions. Unlike diaryl sulfides, dialkyl and alkyl(aryl) sulfides reacted with fluoroalkyl
- Song, Hai-Xia,Wang, Shi-Meng,Wang, Xiao-Yan,Han, Jia-Bin,Gao, Ying,Jia, Su-Jiao,Zhang, Cheng-Pan
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p. 131 - 140
(2016/11/19)
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- METALLOENZYME INHIBITOR COMPOUNDS
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The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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Page/Page column 42
(2013/07/31)
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- AMIDINE COMPOUNDS AND USE THEREOF FOR PLANT DISEASE CONTROL
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An amidine compound represented by formula (1): wherein R1 represent a C1-C11 fluoroalkyl group, a C3-C11 fluoroalkenyl group or a C3-C11 fluoroalkynyl group; R2 represent a C1-C3 alkyl group; R3 represent a C1-C3 alkyl group; R4 represent a C3-C6 cycloalkyl group or a C1-C6 alkyl group optionally having one or more halogens and R5 represent a C3-C6 cycloalkyl group or a C1-C6 alkyl group optionally having one or more halogens, said compound having excellent plant disease controlling effect.
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Page/Page column 127-128
(2012/07/14)
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- METALLOENZYME INHIBITOR COMPOUNDS
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The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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Page/Page column 44
(2011/11/06)
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- Preparation of trifluoromethylated ynamines and their reactions with some electrophilic reagents
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N,N-Dialkyl(3,3,3-trifluoro-1-propynyl)amines were prepared by a three-step procedure starting from commercially available 2,2,3,3,3-pentafluoropropanol. The reactions of these trifluoromethylated ynamines with some electrophiles, such as aldehydes, halog
- Ishihara, Takashi,Mantani, Toshiya,Konno, Tsutomu,Yamanaka, Hiroki
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p. 3783 - 3793
(2007/10/03)
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- NITRILE COMPOUND AND ITS USE IN PEST CONTROL
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The present invention provides a nitrile compound represented by the formula (I): wherein R represents C1-C4 fluoroalkyl, Q represents halogen, C1-C11 alkyl optionally substituted with halogen, C2-C6 alkenyl group optionally substituted with halogen, C2-C6 alkynyl optionally substituted with halogen, C3-C7 cycloalkyl optionally substituted with halogen or (C3-C7 cycloalkyl optionally substituted with halogen)C1-C4 alkyl, which has excellent control effect against pests.
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Page/Page column 124
(2010/02/12)
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- 2,4-DIHYDROXYBENZOIC ACID DERIVATIVES
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The present invention relates to novel compounds of formula (I) and to the salts, solvates and prodrugs thereof, wherein the meanings of the various substituents are as disclosed in the description. Said compounds are useful for the treatment or preventio
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- A new practical and convenient access to the synthesis of N,N-dialkyl-3,3,3-trifluoropropanamides
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N,N-Dialkyl-3,3,3-trifluoropropanamides were readily synthesized in good to excellent yields through N,N-dialkyl(3,3,3-trifluoro-1-propynyl)amines, which were generated by the reaction of N,N-dialkyl(2,2,3,3,3-pentafluoropropyl)-or -(2,3,3,3-tetrafluoro-1
- Yamanaka, Hiroki,Mantani, Toshiya,Shiomi, Keisuke,Ishihara, Takashi
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p. 615 - 616
(2007/10/03)
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