640292-06-4

Basic information

• Product Name: 5-(4-FLUOROPHENYL)ISOXAZOLE-3-CARBOXAL&
• Synonyms: 5-(4-FLUOROPHENYL)ISOXAZOLE-3-CARBOXAL&;5-(4-Fluorophenyl)isoxazole-3-carboxaldehyde 97%
• CAS NO: 640292-06-4
• Molecular Formula: C₁₀H₆FNO₂
• Molecular Weight: 191.1585432
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Isoxazoles
• Mol File: 640292-06-4.mol

Chemical Properties

• Melting Point: 91-95 °C(lit.)
• Boiling Point: 356.9°C at 760 mmHg
• Flash Point: 169.7°C
• Appearance: /
• Density: 1.303g/cm³
• Vapor Pressure: 2.83E-05mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: 5-(4-FLUOROPHENYL)ISOXAZOLE-3-CARBOXAL&(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-FLUOROPHENYL)ISOXAZOLE-3-CARBOXAL&(640292-06-4)
• EPA Substance Registry System: 5-(4-FLUOROPHENYL)ISOXAZOLE-3-CARBOXAL&(640292-06-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 640292-06-4(Hazardous Substances Data)

Usage

Chemical compound

5-(4-fluorophenyl)isoxazole-3-carboxal

Classification

Isoxazole

Main properties

Contains a fluorophenyl group
Isoxazole ring structure
Carboxal group at the 3 position

Specific content

Fluorophenyl group enhances specific interactions with biological targets
Isoxazole-3-carboxal group offers potential for further modification

Application

Used in the synthesis of pharmaceuticals and agrochemicals
Diverse reactivity and biological activities

InChI:InChI=1/C10H6FNO2/c11-8-3-1-7(2-4-8)10-5-9(6-13)12-14-10/h1-6H

Upstream product

• 31686-94-9 ethyl 4-(4-fluorophenyl)-2,4-dioxobutanoate 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 640291-92-5 ethyl 5-(4-fluorophenyl)isoxazole-3-carboxylate 
• 640291-97-0 [5-(4-fluoro-phenyl)-isoxazol-3-yl]-methanol 

Downstream Products

• 640292-11-1 2-{[5-(4-fluorophenyl)isoxazol-3-yl]hydroxymethyl}acrylic acid methyl ester 
• 1378938-14-7 2-amino-3-cyano-7-dimethylamino-4-(5-(4-fluorophenyl)-isoxazol-3-yl)-4H-chromene 
• 1603829-77-1 [5-(4-fluorophenyl)isoxazol-3-yl]-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenylamino]acetonitrile 
• 1426342-55-3 (E)-2-(benzo[d]thiazol-2-yl)-3-[5-(4-fluorophenyl)isoxazol-3-yl]acrylonitrile 

Relevant articles and documents

Novel hybrid molecules of isoxazole chalcone derivatives: Synthesis and study of In Vitro cytotoxic activities

Background: Now-a-days, the model of “hybrid drugs” has acquired recognition in medicine due to their significant role in the treatment of different health problems. Methods: We have synthesized new series of isoxazole-chalcone conjugates (14a-m) by the C

2-Amino-3-cyano-4-(5-arylisoxazol-3-yl)-4H-chromenes: Synthesis and in vitro cytotoxic activity

A new series of 4-aryl-4H-chromenes bearing a 5-arylisoxazol-3-yl moiety at the C-4 position were prepared as potential anticancer agents. The in vitro cytotoxic activity of the synthesized compounds was investigated against a panel of tumor cell lines in

Facile Baylis-Hillman Reaction of Substituted 3-Isoxazolecarbaldehydes: The Impact of a Proximal Heteroatom Within a Heterocycle on the Acceleration of the Reaction

The fast and facile Baylis-Hillman reaction in substituted 3-isoxazolecarbaldehydes confirms the impact of the proximal heteroatom within a heterocycle towards enhanced reactivity of the formyl group for this reaction.