- Synthetic method of flavonoid compound containing CMe2CF3 group
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The invention belongs to the field of chemical synthesis, and particularly relates to a synthetic method of a flavonoid compound containing a CMe2CF3 group; the synthetic method has the characteristics of simple operation, good functional group compatibility and the like, and the flavonoid compound containing the CMe2CF3 group and obtained by reaction has a wide application prospect.
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Paragraph 0026; 0034-0035
(2020/06/17)
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- Organoselenium and DMAP co-catalysis: Regioselective synthesis of medium-sized halolactones and bromooxepanes from unactivated alkenes
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A catalytic system consisting of bis(4-methoxyphenyl)selenide and 4-(dimethylamino)pyridine (DMAP) has been developed for the regioselective synthesis of medium-sized bromo/iodo lactones and bromooxepanes possessing high transannular strain. 77Se NMR, mass spectrometry and theoretical studies reveal that the reaction proceeds via a quaternary selenium intermediate.
- Verma, Ajay,Jana, Sadhan,Prasad, Ch. Durga,Yadav, Abhimanyu,Kumar, Sangit
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supporting information
p. 4179 - 4182
(2016/03/19)
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- The Synthesis of 5-Amino-dihydrobenzo[b]oxepines and 5-Amino-dihydrobenzo[b]azepines via Ichikawa Rearrangement and Ring-Closing Metathesis
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The combination of Ichikawa's rearrangement and a ring-closing metathesis reaction of allyl carbamates is presented as a method for the preparation of 5-amino-substituted 2,5-dihydro-benzo[b]oxepines, 2,5-dihydro-benzo[b]azepines, and 2,5-dihydro-benzo[b]thiepins. It was demonstrated that the use of nonracemic allyl carbamates enables the synthesis of enantioenriched benzo-fused seven-membered heterocycles. Finally, it was shown that further functionalization of the obtained structures allows access to pharmacologically active 5-amino-substituted 2,3,4,5-tetrahydro-1-benzo[b]oxepine scaffolds.
- Chwastek, Monika,Pieczykolan, Micha?,Stecko, Sebastian
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p. 9046 - 9074
(2016/10/17)
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- Tricyclic-isoxazolidine analogues via intramolecular 1,3-dipolar cycloaddition reactions of nitrones
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The tricyclic-isoxazolidine analogues tetrahydrothiochromenoisoxazoles, hexahydroisoxazolequinolines and tetrahydroisoxazolepyranopyridines were prepared by an intramolecular 1,3-dipolar cycloaddition reaction of a nitrone with an alkene. For N-alkylated hexahydroisoxazolequinolines, reduction of the reaction time from two days to 40 min was achieved using microwave heating. The cyclization to form tetrahydroisoxazolepyranopyridines only proceeded when the alkene was substituted with an electron withdrawing group.
- Saubern, Simon,Macdonald, James M.,Ryan, John H.,Woodgate, Ruth C.J.,Louie, Theola S.,Fuchter, Matthew J.,White, Jonathan M.,Holmes, Andrew B.
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experimental part
p. 2761 - 2767
(2010/05/02)
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- Palladium-catalyzed intramolecular carboesterification of olefins
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One catalyst three bonds: The title reaction between propiolic acids and unactivated olefins (see scheme; O red, Cl green) results in vicinal functionalization of the olefin, with the formation of new C-C and C-O bonds. Structurally complex 6,7,5-tricyclic ring systems are formed in a single step by this cascade chloropalladation and formal [3+2] cycloaddition.
- Li, Yang,Jardine, Katherine J.,Tan, Runyu,Song, Datong,Dong, Vy M.
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p. 9690 - 9692
(2010/04/28)
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- Synthesis of 3-substituted-3,4-dihydro-2H-1,3-benzothiazin-2-ones via a highly regioselective palladium-catalyzed carbonylation of 2-substituted-2,3- dihydro-1,2-benzisothiazoles
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(Chemical Equation Presented) A novel synthesis of 3-substituted-3,4- dihydro-2H-1,3-benzothiazin-2-ones is described herein. The strategy relies on a highly regioselective palladium-catalyzed carbonylation of 2-substituted-2,3- dihydro-1,2-benzisothiazol
- Rescourio, Gwenaella,Alper, Howard
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p. 1612 - 1615
(2008/09/16)
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