643069-43-6

Basic information

• Product Name: 4-HYDROXY-5-METHOXYQUINOLINE
• Synonyms: 4-HYDROXY-5-METHOXYQUINOLINE;4(1H)-Quinolinone,5-methoxy-(9CI);5-Methoxyquinolin-4-ol;5-methoxyquinolin-4(1H)-one
• CAS NO: 643069-43-6
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18
• Product Categories: METHOXY
• Mol File: 643069-43-6.mol

Chemical Properties

• Melting Point: 118-121 °C
• Boiling Point: 351.8 °C at 760 mmHg
• Flash Point: 166.6 °C
• Appearance: /
• Density: 1.258 g/cm³
• Vapor Pressure: 1.97E-05mmHg at 25°C
• Refractive Index: 1.649
• CAS DataBase Reference: 4-HYDROXY-5-METHOXYQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-5-METHOXYQUINOLINE(643069-43-6)
• EPA Substance Registry System: 4-HYDROXY-5-METHOXYQUINOLINE(643069-43-6)

Safety Data

• Hazardous Substances Data: 643069-43-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-HYDROXY-5-METHOXYQUINOLINE is used as a pharmaceutical agent for its antitumor properties, serving as a potential candidate for the development of drugs targeting cancer treatment. Its ability to exhibit antimicrobial activity also makes it a candidate for treatments against various microbial infections.
Used in Materials Science:
In the field of materials science, 4-HYDROXY-5-METHOXYQUINOLINE is used in the synthesis of coordination compounds, which are vital for creating new materials with specific properties for various applications.
Used in Catalysis:
4-HYDROXY-5-METHOXYQUINOLINE also finds application in catalysis, where the coordination compounds it helps synthesize can act as catalysts to accelerate chemical reactions, contributing to more efficient industrial processes.

InChI:InChI=1/C10H9NO2/c1-13-9-4-2-3-7-10(9)8(12)5-6-11-7/h2-6H,1H3,(H,11,12)

Upstream product

• 213699-52-6 5-[[(3-methoxyphenyl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 

Downstream Products

• 643069-46-9 4-bromo-5-methoxyquinoline 

Relevant articles and documents

PROCESS FOR PREPARING SUBSTITUTED QUINOLIN-4-OL COMPOUNDS

The invention relates to a process for preparing substituted quinolin-4-ol compounds useful for preparing protein tyrosine kinase (PTK) inhibitors which are useful in treating cancer.

Regioselective synthesis of quinolin-4-ones by pyrolysis of anilinomethylene derivatives of Meldrum's acid

Electron-rich and electron-deficient anilinomethylene derivatives of Meldrum's acid cyclize equally efficiently to quinolin-4-ones via imidoylketene intermediates under flash vacuum pyrolysis (FVP) conditions. Georg Thieme Verlag Stuttgart.

Strategic studies in the syntheses of novel 6,7-substituted quinolones and 7- or 6-substituted 1,6- and 1,7-naphthyridones

This paper describes the different strategies devised and applied to overcome the selectivity issues in the syntheses of 6,7-disubstituted-1H-quinolin-4-one, 7-substituted-1H-1,6-naphthyridin-4-one and 6-substituted-1H-1,7-naphthyridin-4-one derivatives. They allowed us to improve the overall yields and the scaling-up feasibility. Several examples illustrate these strategies with their advantages and drawbacks.

Gas-phase pyrolysis in organic synthesis: Rapid green synthesis of 4-quinolinones

Gas-phase pyrolysis of aminomethylene Meldrum's acid derivatives gave quinolinones and/or amines depending on the nature of arylamino moiety. Effect of substituent on reaction rate and nature of pyrolysis products supports the suggested intramolecular nucleophilic substitution reaction via initially formed keteneamine intermediate. Georg Thieme Verlag Stuttgart.

HEPATITIS C VIRUS INHIBITORS

Hepatitis C virus inhibitors are disclosed having the general formula:(I) wherein R1, R2, R3, R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds toinhibit HCV are also disclosed.