COMPOSITION FOR ALKYLATION, AND METHOD FOR DETOXIFICATION OF TOXIC COMPOUND USING THE COMPOSITION
It is an object of the present invention to provide a beneficial composition in order to detoxify the harmful compound containing arsenic etc. effectively and systematically and a method for detoxifying a harmful compound by using the composition. The composition for the alkylation according to the present invention is characterized in that the composition contains a cobalt complex. The method of detoxifying the harmful compound according to the present invention is characterized in that a harmful compound containing at least one element selected from the groups comprising arsenic, antimony and selenium is detoxified by the alkylation of the harmful compound, in the presence of the composition according to the present invention.
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Page/Page column 14
(2009/06/27)
Detoxification system for inorganic arsenic: Transformation of As 2O3 into TMAO by vitamin B12 derivatives and conversion of TMAO into arsenobetaine
A new two-step synthetic pathway developed for the transformation of arsenic trioxide [iAs(iii); As2O3] into arsenobetaine (AB; Me3As+CH2CO2-) involves treatment of iAs(iii) with native B12 or biomimetic B12 in the presence of glutathione (GSH) to give TMAO with a high selectivity and a high conversion rate; subsequent treatment of TMAO with iodoacetic acid in the presence of GSH gives arsenobetaine. The Royal Society of Chemistry.
Synthesis of trimethylated phosphonium and arsonium analogues of the osmoprotectant glycine betaine; contrasted biological activities in two bacterial species
Phosphoniobetaine and arsenobetaine, the P and As analogues of glycine betaine (trimethylammonioacetate) were synthesized and assayed for activity in bacterial osmoprotection biotests, using Escherichia coli and Rhizobium meliloti as model organisms. The P- and As-betaines displayed similar osmoprotective activities in E. coli, but were highly toxic in the betaine- demethylating bacterium R. meliloti.
Isolation, Crystal Structure and Synthesis of Arsenobetaine, a Constituent of the Western Rock Lobster, the Dusky Shark, and Some Samples of Human Urine
Arsenobetaine has been isolated from the tail muscle of the western rock lobster (Panulirus cygnus George) and from the flesh of the dusky shark (Carcharhinus obscurus Le Sueur), both of which are commercially important seafoods.Trigonelline has also been isolated from the lobster and both arsenobetaine and trigonelline have been isolated from human urine obtained after ingestion of cooked rock lobster. The crystal structures of the monohydrates of arsenobetaine and trigonelline have been determined and a simple synthesis of arsenobetainehas been developed.
Cannon, Jack R.,Edmonds, John S.,Francesconi, Kevin A.,Raston, Colin L.,Saunders, Janice B.,et al.
p. 787 - 798
(2007/10/02)
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