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64527-19-1

(2S)-2-[(4-acetamidophenyl)sulfonylamino]-4-methyl-pentanoic acid is a complex organic compound with the molecular formula C14H20N2O6S. It is a chiral molecule, with the "2S" indicating that it has the S configuration at the second carbon atom. (2S)-2-[(4-acetamidophenyl)sulfonylamino]-4-methyl-pentanoic acid features a 4-methylpentanoic acid backbone, to which a sulfonylamino group is attached. The sulfonylamino group consists of a sulfonyl group (-SO2-) connected to an amino group (-NH2), which is further connected to a 4-acetamidophenyl ring. The 4-acetamidophenyl ring is a derivative of aniline, where the hydrogen at the 4-position is replaced by an acetamido group (-NHCOCH3). This chemical structure is significant in the field of pharmaceuticals, as it is a key component in the synthesis of certain drugs, particularly those with analgesic and anti-inflammatory properties.

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  • 64527-19-1 Structure

  • Basic information

    1. Product Name: (2S)-2-[(4-acetamidophenyl)sulfonylamino]-4-methyl-pentanoic acid
    2. Synonyms: (2S)-2-[(4-acetamidophenyl)sulfonylamino]-4-methyl-pentanoic acid;(S)-2-(4-acetamidophenylsulfonamido)-4-methylpentanoic acid
    3. CAS NO:64527-19-1
    4. Molecular Formula: C14H20N2O5S
    5. Molecular Weight: 328.384
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 64527-19-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (2S)-2-[(4-acetamidophenyl)sulfonylamino]-4-methyl-pentanoic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: (2S)-2-[(4-acetamidophenyl)sulfonylamino]-4-methyl-pentanoic acid(64527-19-1)
    11. EPA Substance Registry System: (2S)-2-[(4-acetamidophenyl)sulfonylamino]-4-methyl-pentanoic acid(64527-19-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 64527-19-1(Hazardous Substances Data)

64527-19-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 64527-19-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,5,2 and 7 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 64527-19:
(7*6)+(6*4)+(5*5)+(4*2)+(3*7)+(2*1)+(1*9)=131
131 % 10 = 1
So 64527-19-1 is a valid CAS Registry Number.

64527-19-1Downstream Products

64527-19-1Relevant articles and documents

Novel 2,3-disubstituted quinazoline-4(3H)-one molecules derived from amino acid linked sulphonamide as a potent malarial antifolates for DHFR inhibition

Patel, Tarosh S.,Vanparia, Satish F.,Patel, Urmila H.,Dixit, Ritu B.,Chudasama, Chaitanya J.,Patel, Bhavesh D.,Dixit, Bharat C.

, p. 251 - 265 (2017/02/26)

An optimization of a modified Grimmel's method for N-heterocyclization of Leucine linked sulphonamide leading to 2,3-disustituted-4-quinazolin-(3H)-ones was accomplished. Further, nineteen hybrid quinazolinone motifs (5a-5s) were synthesized by N-heterocyclization reaction under microwave irradiation using TEAA (IL) as green solvent as well as catalyst. The in vitro screening of the hybrid entities against the plasmodium species P. falciparum yielded five antimalarial potent molecules 5g, 5l, 5m, 5n & 5p owing comparable activity to the reference drugs. The active scaffolds were further evaluated for enzyme inhibition efficacy against alleged receptor Pf-DHFR computationally as well as in vitro, proving their candidature as lead dihydrofolate reductase inhibitors. The prediction of the ADMET properties of the potent molecules also indicated their good oral bioavailability.

PROLINAMIADE DERIVATIVES AS THROMBIN INHIBITOR, PREPRARATION METHOD AND APPLICATION THEREOF

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Page/Page column, (2013/11/19)

Provided are a compound of formula (I), pharmaceutically acceptable salts thereof, preparation methods and applications thereof for inhibiting thrombin, and applications in the treatment and prevention of thrombin-mediated and thrombin-related diseases.

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