- NEW PYRIDINE DERIVATIVES AS LEPTIN RECEPTOR MODULATOR MIMETICS
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The present invention relates to new compounds of formula (I), to pharmaceutical compositions comprising these compounds and to the use of these compounds as leptin receptor modulator mimetics in the preparation of medicaments against conditions associated with weight gain, type 2 diabetes and dyslipidemias.
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Page/Page column 29-30
(2009/12/28)
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- The Pyridine-catalysed Reaction of Methanol with Phenyl Isocyanate in Tetrachloromethane
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The title reaction is first order in catalyst and each reactant.Several 3- and 4-substituted pyridine catalysts generate a Broensted plot with slope β of 0.49.This, the steric effect of 2,4,6-trimethylpyridine, the deuterium isotope effect, and the solvent effect are consistent with the general base mechanism of catalysis.The nucleophilic mechanism is considered relatively unlikely. 2-Pyridylmethanol reacts with phenyl isocyanate faster than does 4-pyridilmethanol, indicating intramolecular general base catalysis in the former case.
- Moodie, Roy B.,Sansom, Peter J.
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p. 664 - 669
(2007/10/02)
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