64608-72-6

Basic information

• Product Name: (1H-PYRROL-2-YL)METHANAMINE
• Synonyms: RARECHEM AL BW 1246;(1H-PYRROL-2-YL)METHANAMINE;1H-Pyrrole-2-MethanaMine;(1H-PYRROL-2-YL)METHANAMINE hcl;1H-pyrrole-2-MethanaMine (HCl salt);(1H-Pyrrol-2-yl)-MethylaMine;2-(Aminomethyl)pyrrole;1-(1H-Pyrrol-2-yl)methanamine
• CAS NO: 64608-72-6
• Molecular Formula: C₅H₈N₂
• Molecular Weight: 96.13
• Mol File: 64608-72-6.mol

Chemical Properties

• Boiling Point: 217.503 °C at 760 mmHg
• Flash Point: 107.706 °C
• Appearance: /
• Density: 1.096 g/cm³
• PKA: 17.47±0.50(Predicted)
• CAS DataBase Reference: (1H-PYRROL-2-YL)METHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (1H-PYRROL-2-YL)METHANAMINE(64608-72-6)
• EPA Substance Registry System: (1H-PYRROL-2-YL)METHANAMINE(64608-72-6)

Safety Data

• Hazardous Substances Data: 64608-72-6(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
(1H-PYRROL-2-YL)METHANAMINE is used as a synthetic building block for the preparation of various organic compounds, particularly benzodipyrrolic derivatives. These derivatives are evaluated as neutral receptors for anions, which can be crucial in the development of new materials and technologies.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (1H-PYRROL-2-YL)METHANAMINE may be utilized as a key intermediate in the synthesis of novel drug candidates. Its unique structure allows for the creation of molecules with specific biological activities, potentially leading to the development of new therapeutic agents.
Used in Material Science:
(1H-PYRROL-2-YL)METHANAMINE can be employed as a component in the development of advanced materials, such as sensors or catalysts, due to its ability to interact with anions. This application can contribute to the advancement of various technologies, including environmental monitoring and energy production.

Upstream product

• 64-17-5 ethanol 
• 960622-17-7 (E)-pyrrole-2-carboxaldehyde oxime 
• 636-41-9 2-methyl-1H-pyrrole 
• 1172625-18-1 2-(bromomethyl)-1H-pyrrole 
• 4513-94-4 1H-pyrrole-2-carbonitrile 

Downstream Products

• 57734-57-3 2-amino-methylpyrrolidine 
• 1394033-38-5 2-(((1-H-pyrrol-2-yl)methylimino)methyl)phenol 

Relevant articles and documents

A State-of-the-Art Heterogeneous Catalyst for Efficient and General Nitrile Hydrogenation

Cobalt-doped hybrid materials consisting of metal oxides and carbon derived from chitin were prepared, characterized and tested for industrially relevant nitrile hydrogenations. The optimal catalyst supported onto MgO showed, after pyrolysis at 700 °C, magnesium oxide nanocubes decorated with carbon-enveloped Co nanoparticles. This special structure allows for the selective hydrogenation of diverse and demanding nitriles to the corresponding primary amines under mild conditions (e.g. 70 °C, 20 bar H2). The advantage of this novel catalytic material is showcased for industrially important substrates, including adipodinitrile, picolinonitrile, and fatty acid nitriles. Notably, the developed system outperformed all other tested commercial catalysts, for example, Raney Nickel and even noble-metal-based systems in these transformations.

Preparation method of benzylamine compound

The invention discloses a preparation method of a benzylamine compound. The method adopting an aryl methane compound as a raw material comprises the following steps: carrying out an NBS bromination reaction to synthesize a bromobenzyl compound, carrying out an N-hydrocarbylation reaction to synthesize a 1-benzylpyrrolidyl-2,5-dione compound, and carrying out a hydrolyzing reaction to obtain the benzylamine compound. The preparation method of the benzylamine compound has the advantages of wide source of the raw material, no need of separation of intermediates generated in above reactions, realization of an all-in-a-pot technology, simple operation, mild reaction conditions, high reaction yield, few three wastes, and convenience for industrial production.