Studies on the secondary structure of bradykinin in aqueous solution. Syntheses, circular dichroism spectra, and bioogical activities of bradykinin analogs containing 5-aminovaleric acid residue
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Hashimoto,Tamaki,Sofuku,Muramatsu
p. 1533 - 1541
(2007/10/02)
Tri- and tetrapeptide analogues of kinins as potential renal vasodilators
Tri- and tetrapeptide analogues were synthesized and evaluated as renal vasodilators. These peptides were prepared by standard coupling reactions which also provided good yields with hindered α-methyl amino acid derivatives. Preliminary evidence of renal vasodilator activity was determined in anesthetized dogs by measuring the effects on renal blood flow and calculating the accompanying changes in renal vascular resistance. The most potent compounds contained, in their structure, the L-prolyl-DL-α-methylphenylalanyl-L-arginine and L-prolyl-DL-α-methyl-phenyalanylglycyl-L-proline arrays. Substitution on the N-terminal proline with 4-phenylbutyryl and 4-(4-hydroxyphenyl)butyryl side chains produced enhanced renal vasodilator activity and, in certain cases, selectivity for the renal vasculature.
Pfeiffer,Chambers,Hilbert,Woodward,Ackerman
p. 325 - 341
(2007/10/02)
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