- TETRAHYDRO-AZEPINOQUINOLINES AS AGONISTS OF THE 5-HT2C RECEPTOR
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Certain tetrahydro-azepinoquinolines of structural formula (I) are agonists of the mammalian 5-HT2c receptor, and, in particular, are selective agonists of the mammalian 5-HT2c receptor. The compounds of the present invention are therefore useful for the treatment, control, or prevention of duseases, conditions, or disorders responsive to stimulation of the 5-HT2c receptor, such as obesity, obesity-related condtions, and certain CNS-related disorders, including schizophrenia and depression. They are also useful as aids for tobacco smoking cessation. Formula (I).
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Page/Page column 52; 53; 67; 68
(2016/03/22)
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- DIPHENYLMETHANE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS
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The instant invention provides compounds of Formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents.
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Page/Page column 44
(2008/06/13)
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- DIPHENYL SUBSTITUTED CYCLOALKANES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE
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The instant invention provides compounds of Formula (I) which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
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Page/Page column 55
(2008/06/13)
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- Effects of oligofluorine substitution on the mutagenicity of quinoline: A study with twelve fluoroquinoline derivatives
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A total of 12 variously fluorinated derivatives of quinoline (Q) were tested for their mutagenicity in Salmonella typhimurium TA100 in the presence of S9 mix to investigate the structure-mutagenicity relationship in oligofluorinated quinolines. Nine of th
- Kato, Taka-Aki,Saeki, Ken-Ichi,Kawazoe, Yutaka,Hakura, Atsushi
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p. 149 - 157
(2007/10/03)
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