- BENZAMIDE COMPOUNDS AS ROR GAMMA MODULATORS
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The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, R1, R2, R3, R4, R5, n and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.
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Page/Page column 29
(2017/12/16)
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- Pd(II)-catalyzed enantioselective C-H activation/C-O bond formation: Synthesis of chiral benzofuranones
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Pd(II)-catalyzed enantioselective C-H activation of phenylacetic acids followed by an intramolecular C-O bond formation afforded chiral benzofuranones. This reaction provides the first example of enantioselecctive C-H functionalizations through Pd(II)/Pd(IV) redox catalysis.
- Cheng, Xiu-Fen,Li, Yan,Su, Yi-Ming,Yin, Feng,Wang, Jian-Yong,Sheng, Jie,Vora, Harit U.,Wang, Xi-Sheng,Yu, Jin-Quan
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supporting information
p. 1236 - 1239
(2013/03/14)
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- NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF
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Compounds of Formula (I) and Formula (II) are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula(I) and Formula (II) have the following structures, where the definitions of the variables are provided herein.
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Page/Page column 143
(2008/12/06)
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- Process for producing an α-aromatic group substituted alkanoic acid derivative
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Compounds having anti-inflammatory and analgesic activity of the formula STR1 are produced from compounds having the formula STR2 by rearrangement in the presence of a base or an amide and (1) X S O X 1 or X S O 2 X 1 where X and X 1 are halogen or trifluoromethyl or (2) sulfur dioxide and halogen.
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- 3-(α,α-Dimethylbenzyl)urea compounds, compositions, and their use as herbicides
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A compound of the general formula (I): STR1 wherein X is halogen or trifluoromethyl, n and m are 0 or 1, R1 is lower C1 - C2 alkyl or C1 - C2 alkoxy and R2 is C4 - C5
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