Ureas in Organic Synthesis. XII. Syntesis of 2-Amino-5-chlorobenzhydrylureas and Their Heterocyclization
A synthetic method was developed for hard-to-get biologically active 2-amino-5-chlorobenzhydrylureas based on reaction of the corresponding benzhydrols with urea in sulfuric acid. The 2-amino-5-chlorobenzhydrylureas were shown to easily undergo on heating cyclization to 1-R-1,2,3,4-tetrahydro-4-phenyl-chloroquinazolin-2-ones.
Bakibaev,Shtrykova,Vostretsov
p. 457 - 459
(2007/10/03)
AMIDE- AND UREA-BASED SYNTHETIC ANTICONVULSANTS, ANTIHYPOXICS, AND INDUCERS OF THE HEPATIC MONOOXYGENASE SYSTEM. IX. SYNTHESIS AND SEARCH FOR INDUCERS OF THE LIVER CYTOCHROME P-450-DEPENDENT MONOOXYGENASE SYSTEM AMONG CARBAMIDE-CONTAINING HETEROCYCLIC COMPOUNDS
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Bakibaev, A. A.,Akhmedzhanov, R. R.,Yagovkin, A. Yu.,Novozheeva, T. P.,Filimonov, V. D.,Saratikov, A. S.
p. 401 - 406
(2007/10/02)
SYNTHESIS OF QUINAZOLINES
Grignard reagents reacted with 2-aminobenzonitrile to give the intermediate (10), which readily could be cyclized to quinazolines by reaction with carbonyl compounds (e.g. acid chlorides, anhydrides, formates and oxalates).The intermediate (10) and aldehy
Bergman, Jan,Brynolf, Anna,Elman, Bjoern,Vuorinen, Eino
p. 3697 - 3706
(2007/10/02)
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