64922-04-9Relevant articles and documents
HIV-1 in strand transfer chelating inhibitors: A focus on metal binding
Bacchi, Alessia,Carcelli, Mauro,Compari, Carlotta,Fisicaro, Emilia,Pala, Nicolino,Rispoli, Gabriele,Rogolino, Dominga,Sanchez, Tino W.,Sechi, Mario,Neamati, Nouri
scheme or table, p. 507 - 519 (2012/03/27)
Most active and selective strand transfer HIV-1 integrase (IN) inhibitors contain chelating functional groups that are crucial feature for the inhibition of the catalytic activities of the enzyme. In particular, diketo acids and their derivatives can coordinate one or two metal ions within the catalytic core of the enzyme. The present work is intended as a contribution to elucidate the mechanism of action of the HIV-IN inhibitors by studying the coordinative features of H2L1 (L-708,906), an important member of the diketo acids family of inhibitors, and H2L2, a model for S-1360, another potent IN inhibitor. Magnesium(II) and manganese(II) complexes of H2L1 and H2L2 were isolated and fully characterized in solution and in the solid state. The crystal structures of the manganese complex [Mn(HL2)2(CH3OH) 2]·2CH3OH were solved by X-ray diffraction analysis. Moreover, the speciation models for H2L2 with magnesium(II) and manganese(II) ions were performed and the formation constants of the complexes were measured. M(HL2)2 (M = Mg 2+, Mn2+) was the most abundant species in solution at physiological pH. All the synthesized compounds were tested for their anti-IN activity, showing good results both for the ligand and the corresponding complexes. From analysis of the speciation models and of the biological data we can conclude that coordination of both metal cofactors could not be strictly necessary and that inhibitors can act as complexes and not only as free ligands.
Aromatic heterocycle compounds having HIV integrase inhibiting activities
-
, (2008/06/13)
A compound of the formula (I): wherein X is hydroxy, protected hydroxy or optionally substituted amino; Y is —COORAwherein RAis hydrogen or ester residue, —CONRBRCwherein RBand RCeach is independently hydrogen or amide residue, optionally substituted aryl or optionally substituted heteroaryl; and A1is optionally substituted heteroaryl; provided that a compound wherein Y and/or A1is optionally substituted indol-3-yl is excluded, a tautomer, a prodrug, a pharmaceutically acceptable salt or a hydrate thereof has an inhibitory activity against an integrase.
INTEGRASE INHIBITORS CONTAINING AROMATIC HETEROCYCLE DERIVATIVES
-
, (2008/06/13)
A compound of the formula (I): whereinX is hydroxy or the like;Y is -C(=R2)-R3-R4 wherein R2 and R3 is oxygen atom or the like, R4 is hydrogen, optionally substituted alkyl, optionally subs
NOVEL PROCESSES FOR THE PREPARATION OF SUBSTITUTED PROPENONE DERIVATIVES
-
Page 24, (2010/11/30)
The present invention provides industrial and commercial processes for the preparation of 2-acyl-5-benzylfuran derivatives, 1,2,4-triazole-3-carboxylic acid ester derivatives and propenone derivatives having anti-HIV activities and usuful crystals thereof. wherein R1, R2 and R4 each is independently hydrogen or the like; A is CR6 or N; R6 is hydrogen or the like; Q is a protecting group; and L is a leaving group.
A practical synthesis of ethyl 1,2,4-triazole-3-carboxylate and its use in the formation of chiral 1',2'-seco-nucleosides of ribavirin
Vemishetti,Leiby,Abushanab,Panzica
, p. 651 - 654 (2007/10/02)
A practical and efficient synthesis of ethyl 1,2,4-triazole-3-carboxylate (6a, R'' = H) from ethyl carboethoxyformimidate hydrochloride is described. Alkylation of this heterocycle with the chloromethyl ethers of 1,3-O-dibenzylbutane-1,2R,3S-triol and 1,3
PREPARATION OF 3- AND 3,5-SUBSTITUTED 1,2,4-TRIAZOLES
Vanek, Tomas,Velkova, Vlasta,Gut, Jiri
, p. 2492 - 2495 (2007/10/02)
Ethyl 1,2,4-triazole-3-carboxylate (V), its 5-methyl and 5-phenyl derivatives (V and VI, respectively), 3-methyl-1,2,4-triazole (VIII), 3-phenyl-1,2,4-triazole (IX), 3,5-dimethyl-1,2,4-triazole (X), 3,5-diphenyl-1,2,4-triazole (XI) and 3-phenyl-5-methyl-1,2,4-triazole (XII) were prepared in 40-70percent yields by thermal cyclization of acylamidrazones III.
