- Novel improved synthesis of hsp70 inhibitor, pifithrin-μ in vitro synergy quantification of pifithrin-μ combined with pt drugs in prostate and colorectal cancer cells
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We describe a novel improved approach to the synthesis of the important and well-known heat shock protein 70 inhibitor (HSP70), pifithrin-μ, with corresponding and previously unreported characterisation. The first example of a combination study comprising
- McKeon, Aoife M.,Egan, Alan,Chandanshive, Jay,McMahon, Helena,Griffith, Darren M.
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- Near-infrared multifunctional photo-thermal agent as well as preparation method and application thereof
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The invention relates to the technical field of medicines, in particular to a near-infrared multifunctional photo-thermal agent and a preparation method and application thereof. The near-infrared multifunctional photo-thermal agent is as shown in the formula I. The near-infrared multifunctional photothermal agent of the formula i, can specifically inhibit the heat shock protein HSP70 existing in the cell and can target the positioning endoplasmic reticulum, and is almost non-toxic to normal cells. 808 nm (0.33 W/cm) Of near-infrared multifunctional photo-thermal agent at low power2 Under laser irradiation, apoptosis can be effectively induced in a low-temperature environment of about 43 °C, growth of tumors is greatly inhibited, good low-temperature photo-thermal therapy is achieved, and damage to normal tissues around is avoided.
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Paragraph 0024; 0029; 0031; 0036
(2021/09/22)
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- HSP70 INHIBITORS AND METHODS OF USING SAME
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The disclosure provides compounds, and compositions comprising such compounds, that can be used to treat cancer, especially colorectal cancer (CRC). In certain embodiments, the compounds of the disclosure inhibit HSP70. In other embodiments, the compounds of the disclosure promote or increase immune cell recruitment to a cancer. In yet other embodiments, the compounds of the disclosure promote or increase immune cell infiltration in a cancer.
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Page/Page column 67; 73-74
(2021/10/11)
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