The Acceleration of the Rearrangement of α-Hydroxy Aldimines by Lewis or Bronsted Acids
An efficient method was developed for the synthesis of α-amino ketones from α-hydroxy imines. The reaction occurs through an α-iminol rearrangement involving the migration of a substituent of the carbinol carbon to the imine carbon. The optimal catalysts were found to be silica gel or montmorillonite K 10, which effected migration of a variety of aryl and alkyl substituents in high yields. The rearrangement can also be carried out on imines generated in situ from aldehydes and amines in essentially the same yields as those from the preformed imines.
Zhang, Xin,Dai, Yijing,Wulff, William D.
p. 2015 - 2018
(2018/09/18)
ORGANIC LUMINOGENS
Small molecule compounds having aggregation-induced emission (AIE) characteristics. The compounds include organic, aromatic salts having anion-π+ interactions. In some embodiments, the anion-π+ interactions can include heavy-atom-ani
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Page/Page column 42
(2018/12/14)
Thiazolium-derived N-heterocyclic carbene-catalyzed cross-coupling of aldehydes with unactivated imines
Cross-coupling of aromatic aldehydes or benzoins with unactivated imines catalyzed by an N-heterocyclic carbene (NHC) affords α-amino ketones smoothly. The Royal Society of Chemistry.
Li, Gong-Qiang,Dai, Li-Xin,You, Shu-Li
p. 852 - 854
(2007/10/03)
Synthesis and antiinflammatory activity of 2,3-bis(p-methoxyphenyl)indole and related compounds.