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N-(2-(BROMOMETHYL)-5-NITROPHENYL)ACETAMIDE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 651733-07-2 Structure
  • Basic information

    1. Product Name: N-(2-(BROMOMETHYL)-5-NITROPHENYL)ACETAMIDE
    2. Synonyms: N-(2-(BROMOMETHYL)-5-NITROPHENYL)ACETAMIDE
    3. CAS NO:651733-07-2
    4. Molecular Formula: C9H9BrN2O3
    5. Molecular Weight: 273.08
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 651733-07-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(2-(BROMOMETHYL)-5-NITROPHENYL)ACETAMIDE(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(2-(BROMOMETHYL)-5-NITROPHENYL)ACETAMIDE(651733-07-2)
    11. EPA Substance Registry System: N-(2-(BROMOMETHYL)-5-NITROPHENYL)ACETAMIDE(651733-07-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 651733-07-2(Hazardous Substances Data)

651733-07-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 651733-07-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,5,1,7,3 and 3 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 651733-07:
(8*6)+(7*5)+(6*1)+(5*7)+(4*3)+(3*3)+(2*0)+(1*7)=152
152 % 10 = 2
So 651733-07-2 is a valid CAS Registry Number.

651733-07-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[2-(bromomethyl)-5-nitrophenyl]acetamide

1.2 Other means of identification

Product number -
Other names 2-acetamido-4-nitrobenzyl bromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:651733-07-2 SDS

651733-07-2Relevant articles and documents

Nitroaryl phosphoramide compositions and methods for targeting and inhibiting undesirable cell growth or proliferation

-

Page 11, (2010/02/09)

The present invention relates to nitroaryl-substituted phosphoramide prodrug compounds and methods of producing the same for use in targeting and inhibiting undesirable cell growth or proliferation.

Nitroaryl Phosphoramides as Novel Prodrugs for E. coli Nitroreductase Activation in Enzyme Prodrug Therapy

Hu, Longqin,Yu, Chengzhi,Jiang, Yongying,Han, Jiye,Li, Zhuorong,Browne, Patrick,Race, Paul R.,Knox, Richard J.,Searle, Peter F.,Hyde, Eva I.

, p. 4818 - 4821 (2007/10/03)

Cyclic and acyclic nitroaryl phosphoramide mustard analogues were activated by E. coli nitroreductase, an enzyme explored in GDEPT. The more active acyclic 4-nitrobenzyl phosphoramide mustard (7) showed 167 500x selective cytotoxicity toward nitroreductase-expressing V79 cells with an IC50 as low as 0.4 nM. This is about 100x more active and 27x more selective than CB1954 (1). The superior activity was attributed to its better substrate activity (kcat/Km 19x better than 1) and/or excellent cytotoxicity of phosphoramide mustard released.

Nitrobenzocyclophosphamides as potential prodrugs for bioreductive activation: Synthesis, stability, enzymatic reduction, and antiproliferative activity in cell culture

Li, Zhuorong,Han, Jiye,Jiang, Yongying,Browne, Patrick,Knox, Richard J.,Hu, Longqin

, p. 4171 - 4178 (2007/10/03)

In efforts to obtain potential anticancer prodrugs for gene-directed enzyme prodrug therapy using Eschericia coli nitroreductase, a series of four benzocyclophosphamide analogues were designed and synthesized incorporating a strategically placed nitro group in a position para to the benzylic carbon for reductive activation. All four analogues were found to be stable in phosphate buffer at pH 7.4 and 37 °C and were good substrates of E. coli nitroreductase with half lives between 7 and 24 min at pH 7.0 and 37 °C. However, only two analogues 6a and 6c, both with a benzylic oxygen in the phosphorinane ring para to the nitro group, showed a modest 33-36-fold enhanced cytotoxicity in E. coli nitroreductase-expressing cells. These results suggest that good substrate activity and the para benzylic oxygen are required for activation by E. coli nitroreductase. Compounds 6a and 6c represent a new structure type for reductive activation and a lead for further modification in the development of better analogues with improved selective toxicity to be used in gene-directed enzyme prodrug therapy.

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