Effects of amino acid chirality and the chemical linker on the cell permeation characteristics of cyclic prodrugs of opioid peptides
Previously, our laboratory showed that the oxymethyl-modified coumarinic acid (OMCA) cyclic prodrug of the opioid peptide DADLE ([D-Ala 2,D-Leu5]-Enk, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH) exhibited low permeation across both the intestinal
Liederer, Bianca M.,Fuchs, Tarra,Velde, David Vander,Siahaan, Teruna J.,Borchardt, Ronald T.
p. 1261 - 1270
(2007/10/03)
Use of 1-(2-Naphthylsulfonyloxy)-6-nitrobenzotriazole as a Novel Coupling Reagent in the Solid-phase Synthesis of Bioactive Peptides
1-(2-Naphthylsulfonyloxy)-6-nitrobenzotriazole (N-NSBt) has been employed as an efficient coupling reagent in the solid-phase synthesis of bioactive peptides: the peptides were obtained in good yields using both Boc as well as Fmoc chemistry of peptide sy
Kundu, Bijoy,Agarwal, Kamlesh C.
p. 200 - 201
(2007/10/03)
SOLID-PHASE SYNTHESIS OF SOME ANALOGS OF LEU-ENKEPHALIN, β-CASOMORPHIN AND DYNORPHIN
Syntheses of seventeen opioid peptides from families of Leu-enkephalin, β-casomorphin and dynorphin have been described.
Kojro, Elzbieta,Grzonka, Zbigniew
p. 163 - 171
(2007/10/02)
Synthesis of N(α)- and C(α)-derivatives of (D)Ala2, Leu5-enkephalin
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Filippi,Biondi,Filira,Rocchi
p. 713 - 724
(2007/10/02)
Synthesis and pharmacological study of some enkephalin analogs in relation to the plurality of opiate receptors
We have synthesized a series of enkephalin analogs and measured their affinity for each type of 'opiate' receptor, the μ receptor and the δ receptor. Furthermore, we have determined their respective antinociceptive activity after intracerebroventricular i
Audigier,Mazarguil,Gout,Cros
p. 173 - 177
(2007/10/02)
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