Ni(0)-Cu(i): a powerful combo catalyst for simultaneous coupling and cleavage of the C-N bond with cyclization to valuable amide-based pyrroles and 4-pyridones
Unprecedented ligand-tuned Ni(0)-Cu(i) combo catalysis is demonstrated via sequential bond activated domino C-N/C-C coupled annulation with C-N bond cleavage to afford valuable polysubstituted amide-based pyrroles and 4-pyridones selectively from β-ketoan
Roy, Dipanwita,Sarkar, Satinath,Laha, Radha M.,Pramanik, Nabyendu,Maiti, Dilip K.
p. 73346 - 73351
(2015/09/15)
An efficient method for the construction of polysubstituted 4-pyridones via self-condensation of β-keto amides mediated by P2O5 and catalyzed by zinc bromide
A self-condensation cyclization reaction mediated by phosphorus pentoxide (P2O5) and catalyzed by zinc bromide (ZnBr2) is presented for the synthesis of polysubstituted 4-pyridones and 2-pyridones from β-keto amides. A var
Tan, Liquan,Zhou, Peng,Chen, Cui,Liu, Weibing
p. 2681 - 2687
(2014/01/06)
Approach to polysubstituted 4-pyridones from N-Aryl acetoacetamides via a N to C 1,3-acyl migration mediated by sodium persulfate
Mediated by sodium persulfate (Na2S2O8), a series of polysubstituted 4-pyridones were synthesized via self-condensation of N-aryl acetoacetamides, during which a novel N to C 1,3-acyl migration should be involved. The stru
Preparation and Antiinflammatory Activity of 2- and 4-Pyridones
Several N-alkyl- and N-arylacetoamides have been self-condensed to form pyridones.N-Alkylacetoacetamides give 2-pyridones, while N-arylacetoamides give 4-pyridones.In an attempt to develop nonacidic, nonsteroidal antiinflammatory agents, the pyridones were tested in a carrageenan-induced pedal edema assay in rats.While the 2-pyridones were not active, 9 of 17 4-pyridones tested were active, and one compound (4g) had antiinflammatory efficacy in a dose-response assay (ED50 values).Most compounds were considered nontoxic by determination of approximate LD50 values in mice by a standard multidimensional observational assay.
Pierce, James Benjamin,Ariyan, Zaven S.,Ovenden, Gaye Stuart
p. 131 - 136
(2007/10/02)
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